华支睾吸虫与肝细胞癌相关性的研究进展  

Research progress on the correlation between Clonorchis sinensis and hepatocellular carcinoma

作　　者：李远宽 孔凤瑶 齐亚鹏 赵婧菲 向邦德[1] Li Yuankuan;Kong Fengyao;Qi Yapeng;Zhao Jingfei;Xiang Bangde(Department of Hepatobiliary Surgery,Guangxi Medical University Cancer Hospital,Nanning 530021,China;Medical College of Oncology,Guangxi Medical University,Nanning 530021,China;Department of General Surgery,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450008,China)

机构地区：[1]广西医科大学附属肿瘤医院肝胆外科,南宁530021 [2]广西医科大学肿瘤医学院,南宁530021 [3]郑州大学附属肿瘤医院普外科,郑州450008

出　　处：《中华肝胆外科杂志》2023年第2期142-147,共6页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金项目(81960450);广西医学高层次骨干人才"139"计划(G201903001);区域性高发肿瘤早期防治研究教育部重点实验室/广西重点实验室2021年度开放课题(GKE-ZZ202111)。

摘　　要：华支睾吸虫被认为是胆管细胞癌的一级致癌物,但越来越多的研究发现,其与肝细胞癌也有着密切的关系。本文综述了华支睾吸虫的发现和流行情况、历史研究、重点区域研究、动物模型及并发症,总结了华支睾吸虫与肝细胞癌发生发展可能的分子机制,以期深入了解华支睾吸虫与肝细胞癌的相关性,为华支睾吸虫感染对肝细胞癌的影响研究提供新的思路。Clonorchis sinensis is considered a class I carcinogen for cholangiocarcinoma,but an increasing number of studies have found that it is also closely associated with hepatocellular carcinoma.This paper reviews the discovery and prevalence,historical studies,key regional studies,animal models and complications of Clonorchis sinensis,and summarizes the possible molecular mechanisms of Clonorchis sinensis contributing to hepatocellular carcinoma development,in order to gain insight into the correlation between Clonorchis sinensis and hepatocellular carcinoma,and thus to provide new ideas for the study of the effects of Clonorchis sinensis infection on hepatocellular carcinoma.

关 键 词：癌 肝细胞 华支睾吸虫 相关性 进展 

分 类 号：R735.7[医药卫生—肿瘤]