Vitellogenin accumulation leads to reproductive senescence by impairing lysosomal function  

作　　者：Jie Tang Yi-Cheng Ma Yuan-Li Chen Rui-Qiu Yang Heng-Chen Liu Xin Wang Baosen Ni Cheng-Gang Zou Ke-Qin Zhang 

机构地区：[1]Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,School of Life Sciences,Yunnan University,Kunming 650091,China [2]Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease,Institute of Medical Biology,Chinese Academy of Medical Sciences,and Peking Union Medical College(CAMS&PUMC),Kunming 650118,China [3]Faculty of Basic Medicine,Kunming Medical University,Kunming 650500,China [4]Institute of Biology and Environmental Engineering,School of Chemistry,Biology&Environment,Yuxi Normal University,Yuxi 653100,China

出　　处：《Science China(Life Sciences)》2023年第3期439-452,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China (U1802233);the Major Science and Technology Project in Yunnan Province of China (202001BB050001)。

摘　　要：The maintenance of proteostasis is essential for cellular and organism healthspan.How proteostasis collapse influences reproductive span remains largely unclear.In Caenorhabditis elegans,excess accumulation of vitellogenins,the major components in yolk proteins,is crucial for the development of the embryo and occurs throughout the whole body during the aging process.Here,we show that vitellogenin accumulation leads to reproduction cessation.Excess vitellogenin is accumulated in the intestine and transported into the germline,impairing lysosomal activity in these tissues.The lysosomal function in the germline is required for reproductive span by maintaining oocyte quality.In contrast,autophagy and sperm depletion are not involved in vitellogenin accumulation-induced reproductive aging.Our findings provide insights into how proteome imbalance has an impact on reproductive aging and imply that improvement of lysosomal function is an effective approach for mid-life intervention for maintaining reproductive health in mammals.

关 键 词：VITELLOGENIN Caenorhabditis elegans LYSOSOME reproductive senescence 

分 类 号：Q945[生物学—植物学]