环状RNA在非酒精性脂肪性肝病进展中的调控机制及潜在价值  

Regulatory mechanism and potential value of circular RNA in nonalcoholic fatty liver disease progression

作　　者：谢群 王玲玲[3] 王理[1] 姚登福[1] 姚敏[1,3] Xie Qun;Wang Lingling;Wang Li;Yao Dengfu;Yao Min(Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Jiangsu 226001,China;Department of Infectious Diseases,Haian Peoples Hospital,Jiangsu 226600,China;Department of Medical Immunology,Medical School of Nantong University,Jiangsu 226001,China)

机构地区：[1]南通大学附属医院临床医学研究中心,南通226001 [2]海安市人民医院感染性疾病科,南通226600 [3]南通大学医学免疫学系,南通226001

出　　处：《中华肝脏病杂志》2022年第11期1270-1275,共6页Chinese Journal of Hepatology

基　　金：国家自然科学基金面上项目(31872738,81873915,81673241)。

摘　　要：非酒精性脂肪性肝病(NAFLD)或称代谢相关脂肪性肝病已成为全球最常见慢性肝病。NAFLD与非编码RNA(ncRNA)关系,已引起基础及临床研究的重视。在脂代谢相关ncRNA中,环状RNA(circRNA)在真核细胞中存在高度保守,异同于含5’’-末端和3’’-末端的线性ncRNAs,具有组织特异性且可稳定表达内源性ncRNA,在封闭、环状核苷链上含miRNA结合位点,形成circRNA-miR-mRNA轴或与蛋白质构成网络,以海绵样机制竞争内源RNA,发挥其抑制或促进相关靶基因表达,参与NAFLD进展。现综述circRNA在NAFLD调控机制、检测技术及其潜在临床价值。Nonalcoholic fatty liver disease(nonalcoholic fatty liver disease,NAFLD)or metabolic-associated fatty liver disease,has become the most common chronic liver disease worldwide.In recent years,the relationship between NAFLD and non-coding RNA(ncRNA)has attracted the attention of basic and clinical researchers.Circular RNA(circRNA)is a lipid metabolism-related non-coding RNA(ncRNA)that is highly conserved in eukaryotic cells and resembles but differs from linear ncRNAs at their 5'-and 3'-terminal ends.With tissue-specific and steady expression of endogenous ncRNA,miRNA binding sites are contained on closed and circular nucleoside chains,forming the circRNA-miR-mRNA axis or network with proteins,competing with endogenous RNA sponge-like mechanisms,playing a role in inhibiting or promoting the expression of related target genes,and participating in the progression of NAFLD.This paper reviews the circRNA regulatory mechanism,detection technology,and potential clinical value in NAFLD.

关 键 词：非酒精性脂肪性肝病 机制 潜在价值 环状RNA 

分 类 号：R575.5[医药卫生—消化系统]