肝硬化门静脉血栓形成机制和治疗新认识  

New recognition of portal vein thrombosis mechanism and treatment in cirrhosis

作　　者：吴治念 肖滢 王亚东[1] Wu Zhinian;Xiao Ying;Wang Yadong(Department of Infectious Diseases,the Third Affiliated Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院感染科,石家庄050035

出　　处：《中华肝脏病杂志》2022年第11期1280-1284,共5页Chinese Journal of Hepatology

基　　金：河北省自然科学基金(H2020206036);河北省科技厅重点研发计划项目(21377756D)。

摘　　要：门静脉血栓(PVT)是肝硬化常见并发症之一, 通过升高门静脉压力, 诱发或加重腹水、上消化道出血, 甚至增加肝移植难度, 影响患者预后。近年来, 随着PVT相关研究结果公布, 对其机制和临床危害认识不断深入。现就PVT形成机制与治疗策略的最新进展进行综述, 以期提升临床医师对PVT发病机制的认识, 辅助制定合理防治策略。Portal vein thrombosis(PVT)is one of the common complications of cirrhosis,which induces or aggravates ascites and upper gastrointestinal bleeding and even impacts the difficulty of liver transplantation by raising portal pressure,hence deteriorating the prognosis of patients.With the revelation of PVT-related research findings in recent years,the recognition of its mechanism and clinical risks has deepened.This article reviews the latest progress in PVT formation mechanisms and treatment strategies to improve clinicians'recognition of the pathogenesis and aid in formulating reasonable prevention and treatment.

关 键 词：肝硬化 门静脉血栓 凝血机制 抗凝 溶栓 经颈静脉肝内门体分流术 

分 类 号：R575.2[医药卫生—消化系统]