1例T细胞淋巴瘤患者的自身抗体对实验室检测结果的干扰  

The Interference of Autoantibodies in a Patient with T-Cell Lymphoma to Laboratory Test Results

作　　者：裴玉玲 车殿茹 郭娟 李璐瑶 张思维[1] 许兴[1] 田恩冰[1] PEI Yuling;CHE Dianru;GUO Juan;LI Luyao;ZHANG Siwei;XU Xing;TIAN Enbing(Department of Clinical Laboratory,Tongzhou District of Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 101121,China)

机构地区：[1]北京中医药大学东直门医院通州院区检验科,北京101121

出　　处：《标记免疫分析与临床》2022年第12期2026-2029,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的确定1例T细胞淋巴瘤患者自身抗体的类型,并分析其对实验室检测结果的影响。方法判读全血细胞分析的结果,确认标本是否存在冷凝集现象;利用血浆置换的方法消除冷凝集素对实验室结果的影响,通过冷凝集素试验测定其效价;通过患者的临床表现和直接抗人球蛋白试验确定患者是否存在温抗体。结果本例患者体内兼有冷凝集素和温抗体。结论凝集标本容易造成实验室工作人员对全血细胞分析结果和血型检测的误判,在工作中要引起高度重视,避免后续的诊疗活动对患者造成伤害。Objective To determine the type of autoantibodies in the studied patient and analyze their impacts on laboratory test results.Methods The results of whole blood cell analysis were interpreted to confirm whether the sample had cold agglutination;Plasma exchange was used to eliminate the effect of cold agglutinin on laboratory results and its titer was determined by cold agglutinin test;The presence of warm antibody was determined by clinical manifestations and direct anti-human globulin test.Results The studied patient had both cold agglutination and warm antibody.Conclusion The agglutination of samples is likely to cause the laboratory staff to misjudge the whole blood cell analysis results and blood type detection,which should be highly alerted in the work to avoid the subsequent misdiagnosis and treatment activities which could cause harmful outcomes to patients.

关 键 词：冷凝集素 温抗体 自身免疫性溶血性贫血 直接抗人球蛋白试验 

分 类 号：R733.4[医药卫生—肿瘤]