肝窦阻塞综合征研究进展  

Research progress of hepatic sinusoidal obstruction syndrome

作　　者：柯子良 刘玉兰[1] Ke Ziliang;Liu Yulan(Department of Gastroenterology,Peking University People's Hospital,Beijing 100044)

机构地区：[1]北京大学人民医院消化科,北京100044

出　　处：《中华肝脏病杂志》2022年第12期1298-1303,共6页Chinese Journal of Hepatology

摘　　要：肝窦阻塞综合征(HSOS)是一种以肝窦内皮细胞损伤为起始病变的肝脏血管性疾病,严重HSOS病死率超过80%。因而HSOS的早诊早治对于延缓该病进展、降低病死率至关重要。但目前临床医师对该病的认识仍然存在不足,且该病的临床表现与其他病因引起的肝脏疾病相似,导致该病的误诊率较高。本文主要对HSOS的病因及发病机制、临床表现及辅助检查、诊断标准、治疗及预防的最新进展进行介绍。Hepatic sinusoidal obstruction syndrome(HSOS)is a hepatic vascular disease that begins with injury to hepatic sinusoidal endothelial cells,and has a fatality rate of over 80%in its severe form.Therefore,early diagnosis and treatment are crucial to delay HSOS progression and reduce mortality.However,clinicians'understanding of the disease is still insufficient,and the clinical manifestations of the disease are similar to liver diseases caused by other etiologies,resulting in a high rate of misdiagnosis.This article mainly introduces the HSOS recent developments in the etiology and pathogenesis,clinical manifestations and auxiliary examinations,diagnostic criteria,treatment,and prevention.

关 键 词：肝窦阻塞综合征 肝小静脉闭塞病 诊断 治疗 临床预防 进展 

分 类 号：R575[医药卫生—消化系统]