乙醛脱氢酶2在肝脏疾病中的研究进展  

Research progress of acetaldehyde dehydrogenase 2 in liver diseases

作　　者：杨星宇 罗军 陈博宇 陈俏 刘忠忠 叶啟发[1] Yang Xingyu;Luo Jun;Chen Boyu;Chen Qiao;Liu Zhongzhong;Ye Qifa

机构地区：[1]武汉大学中南医院、武汉大学肝胆疾病研究院、武汉大学移植医学中心、移植医学技术湖北省重点实验室,武汉430071

出　　处：《中华肝脏病杂志》2022年第12期1397-1400,共4页Chinese Journal of Hepatology

基　　金：武汉大学医学腾飞计划(TFLC 2018003)。

摘　　要：乙醛脱氢酶2(ALDH2)是线粒体内一种重要的醛脱氢酶,具有清除乙醛和其他有毒醛类物质的作用,在肝脏中含量丰富,且与多种肝脏疾病的发生与发展密切相关。在人群中,ALDH2基因多态性对多种肝脏疾病的发生有重要影响。现主要综述近年来ALDH2在肝脏疾病中的研究进展,以期为临床预防和治疗提供理论依据。Acetaldehyde dehydrogenase 2(ALDH2)is an important kind of aldehyde dehydrogenase in mitochondria,which has the function of eliminating acetaldehyde and other toxic aldehydes substances.Furthermore,it is abundant in liver and is closely related to the occurrence and development of a variety of liver diseases.ALDH2 genetic polymorphisms plays an important role in the occurrence of a variety of liver diseases in the human population.This paper mainly reviews the research progress of ALDH2 in liver diseases in recent years,with a view to provide theoretical basis for clinical prevention and treatment.

关 键 词：酒精性肝病 乙醛脱氢酶2 肝细胞癌 分子机制 

分 类 号：R575[医药卫生—消化系统]