Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice  

作　　者：Zitao Guo Dalong Yi Bo Hu Lingyu Zhu Ji Zhang Yuliang Yang Chunyu Liu Yi Shi Zhenghua Gu Yu Xin Huaigao Liu Liang Zhang 

机构地区：[1]National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing,Jiangnan University,Wuxi 214122,China [2]Jiangsu Provincial Research Center for Bioactive Product Processing Technology,Jiangnan University,Wuxi 214122,China [3]Anhui Guotai Biotechnology Co.,Ltd,Xuancheng 242100,China [4]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China

出　　处：《Food Science and Human Wellness》2023年第5期1637-1645,共9页食品科学与人类健康（英文）

基　　金：support from the staff of the National Engineering Research Center for Functional Food,Jiangnan University;supported by the Postdoctoral Research Funding of Jiangsu Province (2021K269B);National Key Research & Developmental Program of China (2018YFA0900300)。

摘　　要：In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation.

关 键 词：Yak bone collagen hydrolysate PEPTIDES Gut microbiota Short-chain fatty acid Lachnospiraceae 

分 类 号：R285.5[医药卫生—中药学]