Potato protease inhibitors,a functional food material with antioxidant and anticancer potential  

作　　者：Yaotong Liu Yuanyuan Bian Yan Bai Siqi Yu Yuxuan Tian Jie Li Suhong Li Tuoping Li 

机构地区：[1]College of Food Science,Shenyang Agricultural University,Shenyang 110866,China [2]College of Grain Science and Technology,Shenyang Normal University,Shenyang 110034,China [3]College of Pharmaceutical Science,Liaoning University,Shenyang 110036,China

出　　处：《Food Science and Human Wellness》2023年第5期1762-1771,共10页食品科学与人类健康（英文）

基　　金：supported by the Science and Technology Mission Project of Liaoning Province Science and Technology Council(2021JH5/10400016);the Service Local Project of Liaoning Provincial Committee of Education(LSNFW202002);the Science and Technology Mission Project of Shenyang Science and Technology Council(20-207-3-25)。

摘　　要：Potato protease inhibitors(PPIs),as the main component of potato protein isolate,have good safety,nutrition and great market potential.The antioxidant and anticancer properties of PPIs were evaluated with cellbased biological assays.The results showed that when the concentration of PPIs was 5 mg/mL,the peroxyl radical scavenging value was(2119±204)mg VCE/100 g,and the cellular antioxidant activity values were(45.83±3.5)(no PBS wash)and(33.25±4.4)μmol QE/100 g(PBS wash).Cells pretreated with PPIs could significantly prevent the oxidative damage induced by H_(2)O_(2),inhibit the morphological changes of cells and maintain the integrity.Furthermore,PPIs had selective anti-proliferative effects on GIST882 cells(IC50=(10.53±3.87)mg/mL)and demonstrated potent inhibition of the growth,migration and invasion of cancer cells.These findings provide a scientific basis for PPIs as promising candidates for functional foods to aid in the prevention of oxidative damage and cancer.

关 键 词：Potato protease inhibitors Antioxidant activity CYTOPROTECTION Anticancer activity 

分 类 号：TS20[轻工技术与工程—食品科学]