绿茶提取物可致特异质型肝损伤?——与美国最新版药物性肝损伤指南商榷  

Can green tea extract cause specific liver injury?——Discussion of the latest US guidelines on drug-induced liver injury

作　　者：高云娟 赵旭 朱敬肖 柏兆方 王伽伯 肖小河 GAO Yunjuan;ZHAO Xu;ZHU Jingxiao;BAI Zhaofang;WANG Jiabo;XIAO Xiaohe(Senior Department of Hepatology,The Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China;School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer Hospital,Chinese Academy of Medical Sciences,Langfang,Hebei 065001,China;School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China)

机构地区：[1]中国人民解放军总医院第五医学中心肝病医学部,北京100039 [2]成都中医药大学药学院,成都611137 [3]国家癌症中心/国家肿瘤临床医学研究中心/河北中国医学科学院肿瘤医院,河北廊坊065001 [4]首都医科大学中医药学院,北京100069

出　　处：《临床肝胆病杂志》2023年第3期523-526,共4页Journal of Clinical Hepatology

基　　金：国家中医药管理局中医药创新团队及人才支持计划(ZYYCXTD-C-202005)。

摘　　要：近年来,绿茶提取物的潜在肝毒性越来越多的引起了人们的关注。本文通过现有绿茶提取物肝损伤相关研究,结合最新药物肝毒性分类,对其肝损伤的客观性和成因机制进行了系统的阐述和分析。进一步根据绿茶提取物致肝损伤的主要风险因素,提出了安全合理使用此类产品的相关建议,以期为绿茶提取物肝损伤机制的深入研究和风险的防控提供有价值的见解,同时,也为绿茶提取物改善健康状况的治疗性使用提供重要的参考。In recent years, the potential hepatotoxicity of green tea extract(GTE) has attracted more and more attention. With reference to the current studies on liver injury caused by GTE and the latest drug hepatotoxicity classification, this article systematically elaborates on the objectivity and causal mechanisms of liver injury caused by GTE. Based on the main risk factors for liver injury caused by GTE, this article also proposes recommendations for safe and rational use of such products, so as to provide valuable insights for in-depth research on the mechanism of liver injury caused by GTE and risk prevention and control, and meanwhile, it also provides an important reference for the therapeutic use of GTE to improve health conditions.

关 键 词：化学性与药物性肝损伤 儿茶酚胺类 绿茶提取物 

分 类 号：R575[医药卫生—消化系统]