氟康唑联合乳杆菌对RVVC的疗效及免疫因子水平的影响  

Efficacy of Fluconazole Combined with Lactobacillus in Treatment of RVVC and Its Influence on Inflammation Indexes

作　　者：石文印 陈伟鸿 张亚娇 李卫[1] SHI Wenyin;CHEN Weihong;ZHANG Yajiao(Department of Obstetrics and Gynecology,Fourth Affiliated Hospital of Jiangsu University,Jiangsu 212000,China)

机构地区：[1]江苏大学附属第四医院,镇江212000

出　　处：《医学研究杂志》2023年第2期118-124,85,共8页Journal of Medical Research

基　　金：江苏省镇江市科技社会发展项目(SH2021042);江苏省镇江市重点研发计划项目(SH2018045)。

摘　　要：目的探究口服氟康唑联合乳杆菌阴道用药在复发性外阴阴道假丝酵母菌病(recurrent vulvovaginal candidiasis,RVVC)患者中的疗效及对炎性指标水平的影响。方法选取门诊确诊为RVVC的患者120例,并采用随机数字表法分为观察组和对照组,每组60例,对照组口服氟康唑,观察组在此基础上予阴道置乳酸杆菌胶囊,观察两组临床症状消失时间、疗效、不良反应和复发率,比较两组治疗前后外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)评分、生存质量评分、炎症指标[白细胞介素(interleukin,IL)-4、IL-10、肿瘤坏死因子(tumer necrosis factor,TNF)-α、IL-2、干扰素(interferon,IFN)-γ、CD4^(+)、CD8^(+)]水平。结果观察组总有效率明显高于对照组(P<0.05);观察组白带异常恢复的时间、总体不良反应发生率、复发率均较对照组明显减少(P<0.05)。与治疗前比较,两组患者治疗后复查VVC评分均降低(P<0.05),且观察组均较对照组低(P<0.05)。两组治疗后生存质量评分与治疗前比较均升高(P<0.05),且观察组的评分高于对照组(P<0.05)。两组患者治疗后IL-4、IL-10、CD8^(+)水平均低于治疗前(P<0.05),且观察组患者中以上指标水平低于对照组(P<0.05);TNF-α、IL-2、IFN-γ、CD4^(+)、CD4/CD8的水平检测在治疗后高于治疗前(P<0.05),且观察组水平高于对照组(P<0.05)。结论氟康唑联合乳杆菌阴道用药治疗RVVC临床疗效较好,安全性能高,可有效改善免疫细胞和相关细胞因子水平。Objective To explore the efficacy of oral Fluconazole combined with Lactobacillus vaginal medication in patients with recurrent vulvovaginal candidiasis(RVVC)and its influence on the levels of inflammation indicators.Methods A total of 120 patients with RVVC were randomly divided into observation group and control group,60 cases in each group.The patients of control group were given Fluconazole orally,the patients of observation group were given Lactobacillus capsules vaginally on the basis of the control group.The disappearance time of clinical symptoms,clinical efficacy,adverse reactions and recurrenct rate of the two groups were observed.The VVC scores,quality of life scores,the levels of inflammation indicators[interleukin-4(IL-4),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),interferon-γ(IFN-γ),CD4^(+),CD8^(+)]were compared before and after treatment between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the disappearance time of the abnormal leucorrhea,the overall incidence of adverse reactions,and the recurrent rate of the observation group were significantly lower than those of the control group(P<0.05).Compared with before treatment,the VVC scores of the two groups were decreased after treatment(P<0.05),and the scores of the observation group were lower than those of the control group(P<0.05).After treatment,the quality of life scores of the two groups were higher than those before treatment(P<0.05),and the scores of the observation group were higher than those of the control group(P<0.05).After treatment,the level of IL-4,IL-10 and CD8^(+)of the two groups were significantly lower than those beforer treatment(P<0.05),and the levels of above indicators in the observation group was lower than that in the control group(P<0.05).The level of IL-2,TNF-α,IFN-γ,CD4^(+),and CD4/CD8 of the two groups were significantly elevated after treatment than before treatment(P<0.05),and the levels of t

关 键 词：氟康唑 乳杆菌 复发性外阴阴道假丝酵母病 炎性细胞因子 疗效 

分 类 号：R711.31[医药卫生—妇产科学]