二茂铁骨架三齿配体在2-丁酮不对称氢化中的应用  

Development of ferrocene-based tridentate ligands for the asymmetric hydrogenation of 2-butanone

作　　者：方伟 肖人玮 宋静远 陈根强 张绪穆 Wei Fang;Renwei Xiao;Jingyuan Song;Gen-Qiang Chen;Xumu Zhang(Department of Chemistry,Southern University of Science and Technology,Shenzhen 518055,China;Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen 518000,China)

机构地区：[1]南方科技大学化学系,深圳518055 [2]南方科技大学前沿与交叉科学研究院,深圳518055

出　　处：《中国科学：化学》2023年第3期558-563,共6页SCIENTIA SINICA Chimica

基　　金：国家重点基础研究发展规划(编号:2021YFA1500201);国家自然科学基金(编号:21991113,21901107,22171129)资助项目。

摘　　要：尽管酮的不对称氢化已经被研究得非常充分,但是能够应用于脂肪酮不对称氢化的催化体系屈指可数,主要难点在于对映选择性的控制.本文中,我们开发了一系列基于二茂铁骨架的手性PNN和PNP类型的三齿配体,并考察了这些手性配体的铱络合物在2-丁酮不对称氢化中催化活性和对映选择性.当采用手性PNP配体时,最高可以获得99%的转化率和79%的对映选择性.Despite various catalytic systems developed for the asymmetric hydrogenation of ketones,few of them works well for the asymmetric hydrogenation of aliphatic ketones.Herein a series of PNN and PNP type tridentate ligands based on ferrocene were developed and the iridium complex of these ligands were tested in the asymmetric hydrogenation of 2-butanone and up to 79%ee was achieved.

关 键 词：手性三齿配体 不对称氢化 二茂铁 2-丁酮 

分 类 号：O641.4[理学—物理化学] O643.36[理学—化学] O623.41