喉鳞状细胞癌中泛素结合酶E2C、胞浆磷蛋白-1表达与预后相关性  

Correlation between ubiquitin-binding enzyme E2C and cytoplasmic phosphoprotein-1 expression and prognosis in laryngeal squamous cell carcinoma

作　　者：王立娟[1] 韩宇 李佳[1] WANG Lijuan;HAN Yu;LI Jia(Department of Otolaryngology,Baoding Second Hospital,Baoding,Hebei 071000,China)

机构地区：[1]保定市第二医院耳鼻喉科,河北保定071000

出　　处：《国际检验医学杂志》2023年第6期713-718,共6页International Journal of Laboratory Medicine

摘　　要：目的探讨泛素结合酶E2C(UBE2C)、胞浆磷蛋白-1(STMN1)在喉鳞状细胞癌(简称喉鳞癌)中的表达水平及与预后的相关性。方法选取2015年2月至2017年2月在该院进行手术治疗中取得的97例喉鳞癌组织标本作为喉鳞癌组,另外选取对应的癌旁组织标本作为癌旁组。采用免疫组化法检测UBE2C和STMN1在不同组织标本中的表达情况;通过χ^(2)检验分析UBE2C、STMN1表达与喉鳞癌患者临床病理特征的关系;采用多因素Cox回归分析影响喉鳞癌患者预后的相关因素。结果喉鳞癌组UBE2C阳性率高于癌旁组,差异有统计学意义(P<0.05);喉鳞癌组STMN1阳性率高于癌旁组,差异有统计学意义(P<0.05)。临床分期为Ⅲ~Ⅳ期、T分期为T_(3)~T_(4)期、有淋巴结转移的喉鳞癌患者UBE2C、STMN1阳性率均高于临床分期为Ⅰ~Ⅱ期、T分期为T_(1)~T_(2)期、无淋巴结转移的喉鳞癌患者(P<0.05)。UBE2C阴性的喉鳞癌患者5年生存率明显高于UBE2C阳性的喉鳞癌患者,差异有统计学意义(P<0.05);STMN1阴性的喉鳞癌患者5年生存率明显高于STMN1阳性的喉鳞癌患者,差异有统计学意义(P<0.05)。单因素分析结果显示,临床分期为Ⅰ~Ⅱ期、无淋巴结转移、UBE2C阴性、STMN1阴性的喉鳞癌患者5年生存率明显高于临床分期分期为Ⅲ~Ⅳ期、有淋巴结转移、UBE2C阳性、STMN1阳性的喉鳞癌患者(P<0.05)。多因素Cox回归分析结果显示,临床分期为Ⅲ~Ⅳ期、有淋巴结转移、UBE2C阳性、STMN1阳性表达是喉鳞癌患者预后的危险因素(P<0.05)。结论UBE2C、STMN1在喉鳞癌患者中主要呈阳性表达,且与喉鳞癌患者预后密切有关,有望成为喉鳞状细胞癌预后评估的指标。Objective To explore the expression of ubiquitin-conjugating enzyme E2C(UBE2C)and stathmin 1(STMN1)in laryngeal squamous cell carcinoma and their relationship with prognosis.Methods A total of 97 cases of laryngeal squamous cell carcinoma tissue specimens obtained during surgical treatment in a hospital from February 2015 to February 2017 were selected as the laryngeal squamous cell carcinoma group,and the corresponding paracancerous tissue specimens were selected as the paracancerous group.Immunohistochemistry was used to detect the expression of UBE2C and STMN1 in different tissue samples.The relationship between the expression of UBE2C and STMN1 and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma was analyzed by χ^(2) test.Multivariate Cox regression was used to analyze the prognostic factors of patients with laryngeal squamous cell carcinoma.Results The positive rate of UBE2C in laryngeal squamous cell carcinoma group was higher than that in paracancerous group,and the difference was statistically significant(P<0.05).The positive rate of STMN1 in laryngeal squamous cell carcinoma group was higher than that in paracancerous group,and the difference was statistically significant(P<0.05).The positive rates of UBE2C and STMN1 in laryngeal squamous cell carcinoma patients with clinical stage Ⅲ to Ⅳ and T stage T_(3)to T_(4)with lymph node metastasis were higher than those in laryngeal squamous cell carcinoma patients with clinical stage Ⅰ to Ⅱ and T stage T1to T2without lymph node metastasis(P<0.05).The 5-year survival rate of UBE2C negative laryngeal squamous cell carcinoma patients was significantly higher than that of UBE2C positive laryngeal squamous cell carcinoma patients,and the difference was statistically significant(P<0.05).The 5-year survival rate of patients with STMN1 negative was significantly higher than that of patients with STMN1 positive,and the difference was statistically significant(P<0.05).Univariate analysis showed that the 5-year survival

关 键 词：泛素结合酶E2C 胞浆磷蛋白-1 喉鳞状细胞癌 预后 

分 类 号：R739.8[医药卫生—肿瘤]