周细胞在炎症性疾病中的研究进展  

Research progress of pericytes in inflammatory diseases

作　　者：王惠琳 蔡晨婕 陈宇奕 孙雯[1,2] WANG Huilin;CAI Chenjie;CHEN Yuyi;SUN Wen(Jiangsu Province Key Laboratory of Oral Disease,Nanjing Medical University,Nanjing 210029;Stomatological College,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学江苏省口腔疾病研究重点实验室,江苏南京210029 [2]南京医科大学口腔医学院,江苏南京211166

出　　处：《南京医科大学学报（自然科学版）》2023年第3期413-420,共8页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(82071086)。

摘　　要：周细胞是一种包绕微血管壁的间充质细胞。炎症是机体对组织损伤的防御反应,有助于受损组织的修复以及有害物质的清除,但过度的炎症反应也会对机体产生破坏作用,引起疾病。近年来周细胞在炎症中所起的作用逐渐受到重视,周细胞能迅速响应炎症刺激,参与中性粒细胞渗出过程,并通过直接接触、旁分泌以及一系列信号转导途径与内皮细胞相互作用,对维持神经血管单元和生理屏障的稳定极为重要。此外,周细胞自身具有吞噬和抗原递呈的免疫功能,在炎症调节中具有抗炎和促炎的双重作用。因此,周细胞在炎症性疾病中扮演重要角色,同时也为靶向周细胞的治疗提供可能的研究方向。本文回顾周细胞参与炎症反应的机制及其在炎症性疾病中的作用,并对相关治疗的研究进展进行综述。Pericyte,a kind of mesenchymal cell,surrounds the wall of microvessels.Inflammation is the body’s defense response to tissue damage,which is helpful to the proliferation and repair of damaged tissues and the removal of harmful substances.However,excessive inflammatory reaction will also cause damage to the body and cause diseases.Studies in recent years have paid more and more attention to the role of pericytes in inflammation.Pericytes can quickly respond to inflammatory stimulation,regulate neutrophilic infiltration in process,and exert the interaction of endothelial cells through direct contact,paracrine and a series of signal transduction pathways,to maintain stable neurovascular unit and physiological barrier.In addition,pericytes themselves have the immune function of phagocytosis and antigen presentation,and have the dual role of anti-inflammatory and proinflammatory in the regulation of inflammation.These effects make pericytes play an important role in inflammatory diseases,and provide a possible research direction for the treatment of pericytes.This article will review how the pericytes function in inflammation and their role in inflammatory diseases,and review the research progress of related therapies.

关 键 词：周细胞 炎症 中性粒细胞 内皮细胞 糖尿病视网膜病变 脑卒中 肾纤维化 

分 类 号：R780.2[医药卫生—口腔医学]