巩膜成纤维细胞在近视发病机制中的作用  

Roles of scleral fibroblasts in pathogenesis of myopia

作　　者：刘子涵 李佳颖 王宁利[1] 张敬学[1] 程祯 李仕明[1] Liu Zihan;Li Jiaying;Wang Ningli;Zhang Jingxue;Cheng Zhen;Li Shiming(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing 100730,China;Department of Ophthalmology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所、眼科学与视觉科学北京市重点实验室,100730 [2]首都医科大学附属北京天坛医院眼科,100070

出　　处：《国际眼科纵览》2023年第1期79-84,共6页International Review of Ophthalmology

摘　　要：近视发生发展的关键是巩膜重塑,巩膜成纤维细胞在巩膜重塑过程中至关重要。近视巩膜重塑过程中,巩膜成纤维细胞呈现出低合成高降解细胞外基质成分的抗纤维化表型、收缩表型、促炎表型。目前巩膜成纤维细胞的干预靶点主要集中在缺氧刺激、环磷酸腺苷(cyclic adenosine monophosphate,cAMP)分解代谢及基质金属蛋白酶家族(matrix metalloproteinases,MMP)表达,其中抗缺氧药物通过调控缺氧诱导因子(hypoxia-inducible factor,HIF)信号通路,可以减缓实验性近视,值得进一步研究。Scleral remodeling is the key to the onset and development of myopia,and scleral fibroblasts play an important role in scleral remodeling.During scleral remodeling,scleral fibroblasts showed an anti-fibrosis,contractile and pro-inflammatory phenotype with low synthesis and high degradation of extracellular matrix components.Currently,hypoxia stimulation,cyclic adenosine monophosphate(cAMP)catabolism,and matrix metalloproteinases(MMPs)expression are three main targets of myopic scleral fibroblasts.Notably,the antihypoxia drugs could reduce experimental myopia by regulating the hypoxia-inducible factor(HIF)signaling pathway,which is worthy of further study.

关 键 词：成纤维细胞 巩膜重塑 肌成纤维细胞 近视 

分 类 号：R778.11[医药卫生—眼科]