Molecular recognition of itch-associated neuropeptides by bombesin receptors  

作　　者：Changyao Li Youwei Xu Heng Liu Hongmin Cai Yi Jiang H.Eric Xu Wanchao Yin 

机构地区：[1]The CAS Key 1Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China [2]University of Chinese Academy of Sciences,Beijing,China [3]Lingang Laboratory,Shanghai,China [4]School of Life Science and Technology,ShanghaiTech University,Shanghai,China [5]Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan,Guangdong,China

出　　处：《Cell Research》2023年第2期184-187,共4页细胞研究（英文版）

基　　金：Ministry of Science and Technology(China)grants(2018YFA0507002 to H.E.X.);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to H.E.X.);Shanghai Municipal Science and Technology Major Project(H.E.X.);CAS Strategic Priority Research Program(XDB37030103 to H.E.X.);National Natural Science Foundation of China(32130022 to H.E.X.,32171189 to W.Y.,and 31770796 to Y.J.);Youth Innovation Promotion Association of CAS(2021278 to W.Y.);National Science Fund for Excellent Young Scholars(82122067 to W.Y.);Key tasks of the Lingang Laboratory(LG202103-03-05 to W.Y.,and LG202101-01-03 to Y.X.);China Postdoctoral Science Foundation(2021M703341 to H.C.);National Science and Technology Major Project(2018ZX09711002 to Y.J.).In addition,this work was partially supported by High-level new R&D institute(2019B090904008);High-level Innovative Research Institute(2021B0909050003)from Department of Science and Technology of Guangdong Province;W.Y.also gratefully acknowledges the support of Sanofi Scholarship Program.

摘　　要：Dear Editor,Itch,especially persistent itch(or chronic pruritus)in patients with allergic skin diseases and/or neuropathic problems,significantly affects sleep,mood and individual health.Extensive efforts have been made to develop novel therapeutic strategies to fight itch.Unfortunately,there is no FDA-approved treatment for chronic pruritus despite great efforts in antipruritic research in the past few decades.

关 键 词：DISEASES ALLERGIC patients 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]