Combining Serum Procalcitonin Level,Thromboelastography,and Platelet Count to Predict Short-term Development of Septic Shock in Intensive Care Unit  

作　　者：Xue-song ZHAO Zhao-li MENG Tuo ZHANG Hong-na YANG Ji-cheng ZHANG Wei FANG Chun-ting WANG Man CHEN 

机构地区：[1]Department of Critical Care Medicine,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,250021,China [2]Department of Critical Care Medicine,Shandong Provincial Hospital,Cheeloo College of Medicine,Shandong University,Jinan,250021,China [3]The First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital),Jinan,250021,China

出　　处：《Current Medical Science》2023年第1期86-92,共7页当代医学科学（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81903086);the Shandong Provincial Natural Science Foundation of China(No.ZR2019QH014).

摘　　要：Objective Despite the recent advances in diagnosis and treatment,sepsis continues to lead to high morbidity and mortality.Early diagnosis and prompt treatment are essential to save lives.However,most biomarkers can only help to diagnose sepsis,but cannot predict the development of septic shock in high-risk patients.The present study determined whether the combined measurement of procalcitonin(PCT),thromboelastography(TEG)and platelet(PLT)count can predict the development of septic shock.Methods A retrospective study was conducted on 175 septic patients who were admitted to the intensive care unit between January 2017 and February 2021.These patients were divided into two groups:73 patients who developed septic shock were assigned to the septic shock group,while the remaining 102 patients were assigned to the sepsis group.Then,the demographic,clinical and laboratory data were recorded,and the predictive values of PCT,TEG and PLT count for the development of septic shock were analyzed.Results Compared to the sepsis group,the septic shock group had statistically lower PLT count and TEG measurements in the R value,K value,αangle,maximum amplitude,and coagulation index,but had longer prothrombin time(DT),longer activated partial thromboplastin time(APTT),and higher PCT levels.Furthermore,the Sequential Organ Failure Assessment(SOFA)score was higher in the septic shock group.The multivariate logistic regression analysis revealed that PCT,TEG and PLT count were associated with the development of septic shock.The area under the curve analysis revealed that the combined measurement of PCT,TEG and PLT count can be used to predict the development of septic shock with higher accuracy,when compared to individual measurements.Conclusion The combined measurement of PCT,TEG and PLT count is a novel approach to predict the development of septic shock in high-risk patients.

关 键 词：SEPSIS shock THROMBOELASTOGRAPHY PROCALCITONIN PLATELET 

分 类 号：R459.7[医药卫生—急诊医学]