痰火方治疗急性脑梗死(痰热证)的临床疗效及对血清炎性因子的影响  

Efficacy of Tanhuo Formula in the Treatment of Acute Cerebral Infarction with Phlegm-heat Syndrome and Its Influence on Serum Inflammatory Factors

作　　者：刘倩[1] 高利[2] 黄礼媛[2] 宋珏娴[2] 何玉伟[1] 曹丽娟[1] Liu Qian;Gao Li;Huang Liyuan;Song Juexian;He Yuwei;Cao Lijuan(Huguosi Traditional Chinese Medicine Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100035,China)

机构地区：[1]北京中医药大学附属护国寺中医医院,北京100035 [2]首都医科大学宣武医院,北京100053

出　　处：《中国中医急症》2023年第3期486-489,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：北京市科学技术委员会“十病十药”研发专项(Z171100001717012)。

摘　　要：目的观察中药痰火方治疗急性脑梗死(痰热证)的临床疗效及对血清炎性因子的影响。方法将80例患者采用随机数字表分为两组各40例。对照组采用西医常规治疗,治疗组在对照组治疗的基础上予院内协定处方痰火方治疗。对比两组患者在治疗前、治疗7 d、治疗2周时美国国立卫生研究院卒中量表(NIHSS)评分、中医证候积分、痰热证评分变化;对比两组患者在治疗前、治疗2周时血清炎性因子的变化;同时比较两组的总有效率。结果与治疗前相比,治疗7 d及治疗2周时两组患者的NIHSS评分、中医证候积分、痰热证评分均有下降(P<0.05),治疗组下降优于对照组(P<0.05);与治疗前相比,治疗2周时两组患者的血清炎性因子均有下降(P<0.05),治疗组下降优于对照组(P<0.05)。对比,治疗组总有效率为95.00%,高于对照组的75.00%(P<0.05)。结论中药痰火方能够显著改善急性脑梗死(痰热证)患者的预后,降低血清炎性因子水平,抑制急性脑梗死产生的炎性反应。Objective:To investigate the clinical efficacy of Chinese medinine Tanhuo Formula in the treatment of acute cerebral infarction with phlegm-heat syndrome and its influence on serum inflammatory factors.Methods:A total of 80 patients were divided into two groups.40 cases were divided into control group and 40 cases in treatment group.The control group was treated with conventional western medicine.The treatment group was given the in-hospital agreement prescription Tanhuo Formula on the base of western medicine treatment.The changes of NIHSS score,TCM syndrome score,phlegm-heat syndrome scores,inflammatory factors before and after treatment were compared between the two groups,and the total effective rate was compared between the two groups.Results:Compared with before treatment,the NIHSS score,TCM syndrome score,phlegm-heat syndrome score of the two groups were decreased after 7 days and 2 weeks of treatment,and the treatment group was significantly better than that of the control group,the difference was statistically significant(P<0.05).Compared with before treatment,the serum inflammatory factors of the two groups all decreased after 2 weeks of treatment,and the treatment group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the treatment group(95.00%)was higher than that of the control group(75.00%),and the difference was statistically significant(P<0.05).Conclusion:Chinese medicine Tanhuo Formula can significantly improve the prognosis of the acute cerebral infarction with phlegm-heat syndrome,reduce serum inflammatory factors,and inhibit the inflammatory response caused by acute cerebral infarction.

关 键 词：急性脑梗死 痰火方 痰热证 炎性因子 

分 类 号：R743.9[医药卫生—神经病学与精神病学]