健康教育联合γ-氨基丁酸干预中老年人失眠的效果研究  

Effect of health education combined withγ-aminobutyric acid on insomnia in middle-aged and elderly people

作　　者：韦丽琴 邵可可 赵桐 高红兰 吴小云 沈晓晨 夏寅寅 卞宝玉 吕万勇 WEI Li-qin;SHAO Ke-ke;ZHAO Tong(Department of Nutrition,Yancheng First Hospital,Affiliated Hospital of Nanjing University Medical School,Yancheng Jiangsu 224006,China;Department of Clinical Laboratory,Yancheng First Hospital,Affiliated Hospital of Nanjing University Medical School,Yancheng Jiangsu 224006,China;Health Management Center,Yancheng First Hospital,Affiliated Hospital of Nanjing University Medical School,Yancheng Jiangsu 224006,China)

机构地区：[1]南京大学医学院附属盐城第一医院营养科,江苏盐城224006 [2]南京大学医学院附属盐城第一医院检验科,江苏盐城224006 [3]南京大学医学院附属盐城第一医院健康管理中心,江苏盐城224006 [4]江苏省老年学学会老年营养专业委员会,江苏南京210000

出　　处：《临床和实验医学杂志》2023年第4期439-443,共5页Journal of Clinical and Experimental Medicine

摘　　要：目的比较健康教育、健康教育+γ-氨基丁酸2种方法对中老年失眠人群的干预效果。方法2021年1月至3月通过媒体平台发布招募信息,在南京大学医学院附属盐城第一医院营养科门诊进行失眠筛查。前瞻性招募40例失眠患者(年龄≥45岁),使用SPSS随机分组法分为健康教育组(A组)、健康教育+γ-氨基丁酸组(B组),每组20例。B组给予睡眠健康教育及每晚睡前1 h温水冲服γ-氨基丁酸粉剂1袋共4周,A组仅给予睡眠健康教育。4周后,比较两组的匹兹堡睡眠质量指数评分(PSQI)、人体成分、血常规、生化全套、维生素D、褪黑素的指标变化。结果干预4周后,B组PSQI总分中位数为12.00(9.25,14.00)分,明显低于A组[16.00(15.00,16.00)分],差异有统计学意义(P<0.05);干预4周后,B组主观睡眠质量、睡眠潜伏期、睡眠时间、睡眠效率、睡眠紊乱、日间功能障碍评分中位数均明显低于A组,差异均有统计学意义(P<0.05);两组在使用催眠药物评分分布差异无统计学意义(P>0.05)。干预4周后,两组人体成分、血常规、生化指标、维生素D、褪黑素水平比较,差异均无统计学意义(P>0.05)。结论与单纯健康教育相比,健康教育联合γ-氨基丁酸能有效改善中老年人失眠,对人体成分及血常规、生化指标、维生素D、褪黑素无明显影响,安全性好。Objective To compare the intervention effects of health education and health education combined withγ-aminobutyric acid on insomnia in middle-aged and elderly people.Methods From January to March 2021,the recruitment information was released through the media platform,and the insomnia screening was conducted in the Department of Nutrition,affiliated to Yancheng First Hospital,Affiliated of Nanjing University Medicine School.Forty patients with insomnia(age 45 or more)were prospectively recruited,SPSS random grouping method was used to divide patients into health education group(group A)and health education combined withγ-aminobutyric acid group(group B),20 cases in each group.Group B was given sleep health education and one pack ofγ-aminobutyric acid powder with warm water one hour before going to bed every night for four weeks,while group A was given Sleep health education only.Four weeks later,the pittsburgh sleep quality index score(PSQI),human body composition,blood routine examination,biochemical analysis,vitamin D and melatonin data were compared between the two groups.Results After 4 weeks of intervention,the median total scores of PSQI in group B were 12.00(9.25,14.00)points,which were significantly lower than those in group A[16.00(15.00,16.00)points],the differences were statistically significant(P<0.05).After 4 weeks of intervention,the median scores of subjective sleep quality,sleep latency,sleep time,sleep efficiency,sleep disorder,daytime dysfunction scores in group B were significantly lower than those in group A,the differences were statistically significant(P<0.05).There was no significant difference in the score distribution of using hypnotic drugs between the two groups(P>0.05).After the intervention,there was no significant difference between the two groups in human body composition,blood routine examination,biochemical analysis,vitamin D and melatonin data(P>0.05).Conclusion Compared with simple health education,health education combined withγ-aminobutyric acid can effectively improve the

关 键 词：健康教育 Γ氨基丁酸 失眠 中老年人 

分 类 号：R740[医药卫生—神经病学与精神病学]