色酮-3-甲酸合成研究进展  

Advances on the synthesis of chromone 3-carboxylic acid

作　　者：褚朝森[1] 王晓丽[1] 李天雪[1] 苟琼心[1] 闫秀美 CHU Chao-sen;WANG Xiao-li;LI Tian-xue;QOU Qing-xin;YAN Xiu-mei(Lianyungang TCM Branch of Jiangsu Union Technical Institute,Lianyungang 222007,China;Jiangsu Deyuan PharmaceuticaI Co.,Ltd.,Lianyungang 222047,China)

机构地区：[1]江苏联合职业技术学院连云港中医药分院,江苏连云港222007 [2]江苏德源药业股份有限公司,江苏连云港222047

出　　处：《化学研究与应用》2023年第3期500-505,共6页Chemical Research and Application

基　　金：江苏省连云港市第六期“521工程”新医药科研项目(LYG06521202140)资助。

摘　　要：色酮-3-甲酸是黄酮类天然产物的结构单元,属于苯并吡喃型化合物,具有优良的生物活性,如抗菌、抗病毒、抗癌、抗炎、抗氧化等。分子中C-3位上的羧基具有较强的反应活性,可用于制备醛、酯、酰胺、醇等重要的有机合成中间体物质,是进一步构建复杂分子的重要有机砌块,其合成方法持续受到关注并得到了很大发展。在分析色酮-3-甲酸结构特征的基础上,对其合成方法进行了综述,并预测和讨论了该化合物合成今后的发展方向。Chromone 3-carboxylic acid is a structural scaffold for many natural products,such as flavonoids.As a benzopyran,it possesses rich biological activities,including antibacterial,antiviral,anticancer,antiinflammation,antioxidation and so on.The carboxyl group at C-3 has versatile transform ability,which can be converted to aldehyde,ester,amide,alcohol and used to prepare various intermediates.Chromone-3-carboxylic acid is a very important building block for construction of complex molecules.The synthetic methods of chromone-3-carboxylic acid have been attracted much attention.The present syntheses of chromone-3-carboxylic acid were summarized and the future development was discussed.

关 键 词：色酮-3-甲酸 色酮 合成中间体 天然产物 

分 类 号：O629.9[理学—有机化学]