氨基吡啶酯类衍生物的设计、合成及生物活性研究  

Design,synthesis and biological activity of aminopyridine ester derivatives

作　　者：郝岚婧 李杰 张静[1,2] 高一星 张立新[1,2] HAO Lan-jing;LI Jie;ZHANG Jing;GAO Yi-xing;ZHANG Li-xin(Institute of Functional Molecules,Shenyang University of Chemical Technology,Shenyang 110142,China;Guangxi Siyue Biotechnology Co.,Ltd.,Nanning 530000,China)

机构地区：[1]沈阳化工大学功能分子研究所,辽宁沈阳110142 [2]广西思钺生物科技有限责任公司,广西南宁530000

出　　处：《化学研究与应用》2023年第3期600-605,共6页Chemical Research and Application

基　　金：南宁市科学研究与技术开发计划项目立项资助,重大科技专项目(20201043)资助;南宁市创新创业领军人才“邕江计划”创业项目(2020002-1)资助。

摘　　要：为研发出高效的杀菌剂,基于先导化合物Aminopyrifen,对其结构进行修饰,设计并合成了8个未见文献报道的含氨基吡啶酯结构的化合物。其化学结构均经H1NMR和LC-MS确证,且所合成的化合物经生物活性测试结果表明:化合物B-3在100mg·L^(-1)的浓度下对黄瓜霜霉病防效可达到80.3%。本研究为进一步合成杀菌活性较高的氨基吡啶酯类化合物提供参考。To develop a highly efficient fungicide,based on the lead compound aminopyrifen,its structure was modified,and 8 compounds containing aminopyridine ester structures that were not reported in the literature were designed and synthesized.The chemical structure was confirmed by H1NMR and LC-MS,and the bioactivity test results of the synthesized compound showed that compound B-3 could achieve 80.3%anti-cucumber downy mildew at a concentration of 100mg·L^(-1).This study provided a reference for the further synthesis of aminopyridine ester compounds with high bactericidal activity.

关 键 词：杀菌 氨基吡啶酯 合成 

分 类 号：O626[理学—有机化学]