CK7/SATB2/PAX8与肿瘤大小/侧向鉴别原发与下消化道转移性卵巢黏液癌  

THE SIGNIFICANCE OF CK7,SATB2,AND PAX8 COMBINED WITH TUMOR SIZE AND LATERALITY IN DIFFERENTIAL DIAGNOSIS OF PRIMARY AND LOWER GASTROINTESTINAL METASTATIC OVARIAN MUCINOUS CARCINOMA

作　　者：李泓璇 夏男男 宋克娟[2] 张丹[2] 赵涵[3] 姚勤[2] LI Hongxuan;XIA Nannan;SONG Kejuan;ZHANG Dan;ZHAO Han;YAO Qin(Department of Gynecology,Qingdao Women and Children Hospital,Qingdao 266000,China)

机构地区：[1]青岛大学附属青岛市妇女儿童医院妇科,山东青岛266000 [2]青岛大学附属医院妇科 [3]青岛大学附属医院病理科

出　　处：《青岛大学学报（医学版）》2023年第1期122-126,共5页Journal of Qingdao University(Medical Sciences)

基　　金：青岛市民生科技计划项目(19-6-46-nsh)。

摘　　要：目的探讨细胞角蛋白7(CK7)、特殊的含AT序列的结合蛋白2(SATB2)、配对盒基因8(PAX8)联合肿瘤大小、侧向性鉴别诊断原发性与下消化道转移性卵巢黏液癌的意义。方法选取原发性卵巢黏液性肿瘤(PMOC)标本74例,下消化道转移性卵巢黏液癌(MMOC)标本16例,统计肿瘤大小、侧向性,免疫组化方法检测标本CK7、SATB2、PAX8、细胞角蛋白20(CK20)及尾型同源盒转录因子2(CDX2)的表达,分析上述指标在二者鉴别诊断中的意义。结果CK7、PAX8在PMOC组织阳性表达率高于MMOC(P=0.000、0.000),SATB2、CK20、CDX2在MMOC组织阳性表达率高于PMOC(P=0.000,χ^(2)=14.16~17.30,P<0.05);CK7、PAX8、SATB2联合肿瘤大小、侧向性诊断PMOC的准确度分别为82.2%、76.7%、74.4%,CK7/CDX2/CK20诊断PMOC的准确度为76.6%,CK7/PAX8/SATB2/大小/侧向性诊断PMOC准确度、灵敏度、特异度、约登指数分别为94.4%、93.2%、100.0%、93.2%。结论单个指标CK7、PAX8、SATB2可以鉴别PMOC与MMOC,联合肿瘤大小、侧向性诊断效能显著提高。Objective To explore the application of cytokeratin 7(CK7),special AT-rich sequence-binding protein 2(SATB2),and paired box gene 8(PAX8)combined with tumor size and laterality in differential diagnosis of primary mucinous ovarian carcinoma(PMOC)and metastatic mucinous ovarian carcinoma(MMOC)of lower digestive tract.Methods Tumor size and laterality were measured using 74 specimens of PMOC and 16 specimens of MMOC.Immunohistochemical methods were used to detect the expression of CK7,SATB2,PAX8,cytokeratin 20(CK20),and caudal type homeobox 2(CDX2).The significance of the above indicators in the differential diagnosis of PMOC and MMOC was analyzed.Results The positive expression rate of CK7 and PAX8 was higher in PMOC than in MMOC(P=0.000,0.000),and the positive expression rate of SATB2,CK20,and CDX2 was higher in MMOC than in PMOC(P=0.000;χ^(2)=14.16-17.30,P<0.05).The PMOC diagnostic accuracy of CK7,PAX8,and SATB2 combined with tumor size and laterality was 82.2%,76.7%,and 74.4%,respectively.The PMOC diagnostic accuracy of CK7/CDX2/CK20 was 76.6%.The PMOC diagnostic accuracy,sensitivity,specificity,and Youden index of CK7/PAX8/SATB2/tumor size/laterality was 94.4%,93.2%,100.0%,and 93.2%,respectively.Conclusion CK7,PAX8,or SATB2 can be used to differentiate between PMOC and MMOC.The diagnostic efficiency is significantly improved in combination with tumor size and laterality.

关 键 词：卵巢肿瘤 病理学 临床 角蛋白7 配对盒基因8 特殊的含AT序列的结合蛋白2 诊断 鉴别 

分 类 号：R737.31[医药卫生—肿瘤]