江苏省启东地区肝癌患者ABO血型分布及其与肝癌发病风险的关系  

ABO blood type distribution in liver cancer patients in Qidong District of Jiangsu Province and its relationship with the risk of liver cancer

作　　者：孙燕 薛学锋 陆玲玲 严永锋 姜小平 王金兵 吴燕 陈陶阳 SUN Yan;XUE Xuefeng;LU Lingling;YAN Yongfeng;JIANG Xiaoping;WANG Jinbing;WU Yan;CHEN Taoyang(Qidong People’s Hospital,Qidong 226200,China)

机构地区：[1]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院,江苏启东226200

出　　处：《山东医药》2023年第6期16-18,共3页Shandong Medical Journal

基　　金：国家科技重大专项资助项目(2008ZX10002-018;2012ZX10002010-001)。

摘　　要：目的了解江苏省启东地区肝癌患者ABO血型分布情况,探讨ABO血型与肝癌发病风险的关系。方法选择1701例启东籍肝癌患者、2828例排除疾病后的启东籍健康体检人员,采集两组外周静脉血检测ABO血型,分析ABO血型与肝癌发生风险的关系。结果1701例肝癌患者中,血型为A型者518例(30.45%)、B型者436例(25.63%)、O型者518例(30.45%)、AB型者229例(13.46%);2828例体检健康者中,血型为A型者862例(30.48%)、B型者818例(28.93%)、O型者853例(30.16%)、AB型者295例(10.43%),与健康人群比较,肝癌患者中AB型比例高、B型比例低(P均<0.05)。B型的启东籍人群发生肝癌的风险低(OR=0.847,95%CI:0.739~0.970),AB型启东籍人群发生肝癌的风险高(OR=1.336,95%CI 1.111~1.606)。与健康人群比较,男性肝癌患者B型比例低、AB型比例高(χ^(2)=5.618,11.01;OR分别为0.809,1.534;P均<0.05)。结论江苏省启东地区肝癌的发生与ABO血型有关,AB型人群发生肝癌的风险高,B型人群发生肝癌的风险低。Objective To investigate the ABO blood type distribution in liver cancer patients in Qidong District of Ji⁃angsu Province,and to explore the relationship between ABO blood type and the risk of liver cancer.Methods Peripher⁃al venous blood was collected from 1701 patients with liver cancer and 2828 healthy persons from Qidong after disease exclusion to detect ABO blood type,and the relationship between ABO blood type and risk of liver cancer was analyzed.Results The frequency distributions of blood types A,B,O,AB were 518(30.45%),436(25.63%),518(30.45%),and 229(13.46%),respectively,among liver cancer patients,and 862(30.48%),818(28.93%),853(30.16%),and 295(10.43%),respectively,among healthy persons.Compared with healthy persons,the distribution of blood type AB was higher and B distribution was lower in liver cancer patients(both P<0.05).Qidong population with blood type B had a low risk of liver cancer(OR=0.847,95%CI:0.739–0.970),and the population with blood type AB had a high risk of liver cancer(OR=1.336,95%CI:1.111–1.606).Compared with healthy persons,the distribu⁃tion of blood type B was lower and the distribution of AB type was higher in male liver cancer patients(χ^(2)=5.618,11.01;OR=0.809,1.534,respectively;both P<0.05).Conclusion ABO blood type is related to the occurrence of liver can⁃cer in Qidong.The risk of liver cancer is higher in the population with blood type AB and is lower in the population with blood type B.

关 键 词：血型 ABO血型 肝肿瘤 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]