Toll样受体4相关信号通路在缺血性脑卒中炎症损伤中的研究进展  

Recent advance in Toll-like receptor 4 related signaling pathway in inflammatory injury of ischemic stroke

作　　者：李斌[1] 周宇 马勇 柴尔青[2] Li Bin;Zhou Yu;Ma Yong;Chai Erqing(First Clinical Medicine College,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Cerebrovascular Diseases of Gansu Province,Cerebrovascular Disease Center,Gansu Provincial People's Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省人民医院脑血管病中心,甘肃省脑血管病重点实验室,兰州730000

出　　处：《中华神经医学杂志》2023年第2期205-211,共7页Chinese Journal of Neuromedicine

摘　　要：缺血性脑卒中的发生发展机制目前尚未完全阐明,但炎症损伤已被公认在其中起着重要作用。Toll样受体4(TLR4)相关信号通路的激活可促进缺血性脑卒中后相关促炎细胞因子和抗炎细胞因子的表达,从而影响着缺血性脑卒中的进展及预后。笔者现围绕TLR4相关信号通路在缺血性脑卒中炎症损伤中的研究进展进行综述,以期为可用于缺血性脑卒中治疗的靶向TLR4抗炎药物的研发提供一些思路及借鉴。The mechanism of ischemic stroke development has not been fully elucidated,but inflammatory damage has been recognized to play an important role.Activation of Toll-like receptor 4(TLR4)-related signaling pathways can promote the expressions of pro-inflammatory cytokines and anti-inflammatory cytokines associated with ischemic stroke,thereby affecting the progression and prognosis of ischemic stroke.The author reviews the research progress of TLR4-related signaling pathways in inflammatory injury of ischemic stroke,in order to provide some ideas and references for the discovery of targeted TLR4 anti-inflammatory drugs that can be used for ischemic stroke treatment.

关 键 词：TOLL样受体4 缺血性脑卒中 炎症损伤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]