LC3相关吞噬作用调控感染发生发展的研究进展  

Role of LC3-associated phagocytosis in regulating infection

作　　者：王瑜 黄显辉[1] 沈仁 周朝阳 楼永良[1] 谢旦立[1] Wang Yu;Huang Xianhui;Shen Ren;Zhou Chaoyang;Lou Yongliang;Xie Danli(School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,China;Key Laboratory of Laboratory Medicine,Ministry of Education of China,Wenzhou Medical University,Wenzhou 325035,China;Department of Pediatrics,the People′s Hospital of Yuhuan,Taizhou 317699,China;Intensive Care Unit,the People′s Hospital of Yuhuan,Taizhou 317699,China)

机构地区：[1]温州医科大学检验医学院(生命科学学院),温州325035 [2]温州医科大学检验医学教育部重点实验室,温州325035 [3]玉环市人民医院儿科,台州317699 [4]玉环市人民医院重症医学科,台州317699

出　　处：《中华微生物学和免疫学杂志》2023年第2期158-163,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家重点研发计划课题(2021YFC2300302);浙江省自然科学基金(LY22H190002);温州市科技局科技计划项目(Y2020217)。

摘　　要：LC3相关吞噬作用(LC3-associated phagocytosis,LAP)是一种特殊的吞噬作用,存在于吞噬和自噬两条途径的交叉点。LAP过程的标志性事件是微管相关蛋白1轻链3-Ⅱ型(LC3Ⅱ)被募集到单层膜结构的吞噬体表面。LAP途径依赖于含RUN域半胱氨酸丰富域苄氯素1相互作用蛋白(RUN domain and cysteine-rich domain containing,Beclin 1-interacting protein,Rubicon)及还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶的功能,最终导致LC3相关吞噬体(LAPosome)与溶酶体结合,来消化降解内容物。近几年越来越多研究发现,LAP在病原微生物包括真菌、细菌等感染宿主后发挥着重要作用。多数情况下LAP是宿主抵御和降解病原微生物感染的重要途径,但是部分病原微生物在宿主内可以有效逃避LAP的攻击,甚至可以利用LAPosome成为其定居和复制的场所。本研究总结了近几年LAP在宿主抵御病原微生物感染及疾病发生发展方面的最新进展。LC3-associated phagocytosis(LAP)is a special phagocytosis occurring at the intersection of the two pathways of phagocytosis and autophagy.A hallmark event of the LAP process is the recruitment of microtubule-associated proteinⅠlight chain type 3-Ⅱ(LC3Ⅱ)to the phagosome surface of the monolayer membrane structure.The LAP pathway relies on the functions of the RUN domain and cysteine-rich domain containing,Beclin 1-interacting protein(Rubicon)and reduced nicotinamide adenine dinucleotide phosphate(NADPH)oxidase.The LC3-associated phagosome(LAPosome)binds to the lysosome to digest and degrade the contents.In recent years,increasing studies have found that LAP plays an important role in the infections caused by pathogenic microorganisms including fungi and bacteria.LAP is a crucial way in the host to resist and degrade the infection of pathogenic microorganisms.However,some pathogenic microorganisms can effectively escape from LAP in the host and even use LAPosome as a place for colonization and replication.This article summarized the recent progress in the role of LAP in host defense against pathogenic microorganism infection and the significance of it in the occurrence and development of diseases.

关 键 词：LC3相关吞噬作用 病原微生物 感染免疫 

分 类 号：R363[医药卫生—病理学]