清脾泻热汤辅助治疗小儿疱疹性口腔炎心脾积热证63例临床观察  

Clinical observation on 63 cases of herpes stomatitis in children with heat accumulation at heart and spleen syndrome treated by Qingpi Xiere Tang(清脾泻热汤)as adjuvant therapy

作　　者：徐文雄 张康忠 XU Wenxiong;ZHANG Kangzhong(Department of Stomatology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,Zhejiang,325000,China;Department of Pediatrics,Wenzhou People's Hospital,Wenzhou,Zhejiang,325000,China)

机构地区：[1]温州市中西医结合医院口腔科,浙江温州325000 [2]温州市人民医院儿科,浙江温州325000

出　　处：《中医儿科杂志》2023年第1期35-39,共5页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2019ZA101)。

摘　　要：目的观察清脾泻热汤辅助治疗小儿疱疹性口腔炎心脾积热证的临床疗效。方法选取2018年4月至2021年4月温州市中西医结合医院口腔科和儿科门诊收治的疱疹性口腔炎心脾积热证患儿126例,采用随机数字表法分为对照组和治疗组,各63例。对照组采用口泰洗液饭后清洗口腔、利巴韦林气雾剂口腔喷雾,治疗组在对照组治疗方法的基础上给予清脾泻热汤治疗。2组均以7 d为1个疗程,治疗1个疗程后统计疗效。结果对照组总有效率为88.89%(56/63),治疗组为98.41%(62/63),2组比较,差异有统计学意义(P<0.05)。治疗组口腔疱疹及溃疡消退时间、退热时间及食欲改善时间均短于对照组,2组比较,差异有统计学意义(P<0.05)。治疗前2组血清免疫球蛋白(Ig)A、IgG、IgM水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清IgA、IgG、IgM水平均明显升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。治疗前2组血清超敏C-反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清hs-CRP水平均明显降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。结论清脾泻热汤辅助治疗小儿疱疹性口腔炎心脾积热证,能有效改善患儿的临床症状、体征,提高机体免疫力,减轻炎症反应,疗效显著,值得临床推广应用。Objective To observe the clinical efficacy of Qingpi Xiere Tang(清脾泻热汤)in adjuvant treatment of herpetic stomatitis in children with heat accumulation at heart and spleen syndrome.Methods From April 2018 to April 2021,126 cases of herpetic stomatitis in children with heat accumulation at heart and spleen syndrome admitted into Stomatology Department and Pediatrics of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine were divided into a control group and a treatment group in a random number table,with 63 cases in each group.The control group was given oral cleaning with Koutai compound chlorhexidine gargle and oral spray with ribavirin aerosol after meals.The treatment group was given Qingpi Xiere Tang(清脾泻热汤)on the basis of the treatment methods of the control group.The two groups took 7 days as a course of treatment,and the curative effect was statistically analyzed after one course of treatment.Results The total effective rate was 88.89%(56/63)in the control group and 98.41%(62/63)in the treatment group,and the difference was statistically significant between the 2 groups(P<0.05).The time of oral herpes and ulcer fading,fever fading and appetite improvement in the treatment group were shorter than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference in serum IgA,IgG and IgM levels between the two groups(P>0.05),which was comparable.The levels of serum IgA,IgG and IgM in the 2 groups were significantly increased after treatment,and the difference was statistically significant compared with before treatment(P<0.05),and the levels were more significantly increased in the treatment group(P<0.05).Before treatment,there was no significant difference in serum hypersensitive C-reactive protein(hs-CRP)levels between the two groups(P>0.05),which was comparable.After treatment,the serum hs-CRP level in the 2 groups was significantly decreased,and the difference was statisticall

关 键 词：小儿 疱疹性口腔炎 心脾积热证 清脾泻热汤 临床观察 

分 类 号：R781.5[医药卫生—口腔医学]