蛋白质组学在结肠癌研究中的进展  

Progress of proteomics in research of colon cancer

作　　者：吴傲(综述)[1] 张丽军(审校)[1] WU Ao;ZHANG Li-jun(Shanghai Public Health Clinical Center,Shanghai 201508)

机构地区：[1]上海市公共卫生临床中心,上海201508

出　　处：《中国生物制品学杂志》2023年第2期224-229,共6页Chinese Journal of Biologicals

基　　金：国家自然科学基金(81271834);“重大新药创制”科技重大专项(2012ZX09303013);国家863课题(2014AA021403);上海市高等级生物安全病原微生物检测专业技术服务平台(15DZ2290200)。

摘　　要：结肠癌的诊断及治疗一直是医疗界的难题。近年有关结肠癌差异蛋白质的研究越来越多,运用蛋白质组学技术发现癌症组织中的差异蛋白质,并研究其在癌症中的功能及作用,从而用于癌症的诊断和治疗,已成为一种新的趋势。本课题组前期通过蛋白质组学技术发现乳腺癌相关耐药蛋白2(ATP-binding cassette sub-family G member 2,ABCG2)和蛋白质二硫异构酶A2(protein disulfide-isomerase A2,PDIA2)两种结肠癌差异蛋白质,本文对这两种蛋白质在结肠癌中的表达及功能作一综述。The diagnosis and treatment of colon cancer has always been a difficult problem in the medical field.In recent years,there have been more and more researches on differential proteins in colon cancer.It has become a new trend to find differential proteins in cancer tissues by proteomic technology and study their functions and roles in cancer,which was so as to used in cancer diagnosis and treatment.We have found two differential proteins ATP-binding cassette sub-family G member 2(ABCG2)and protein disulfide-isomerase A2(PDIA2)in colon cancer by proteomic technology before,and this article reviews the expression and function of these two proteins in colon cancer.

关 键 词：结肠癌 差异蛋白质 乳腺癌相关耐药蛋白2 蛋白质二硫异构酶A2 

分 类 号：R735.3[医药卫生—肿瘤]