经直肠多模态超声及血清前列腺特异性抗原对临床局限性前列腺癌诊断的预测价值  

Value of transrectal multimodal ultrasound combined with prostate specific antigen in predicting clinically organ-confined prostate cancer

作　　者：李廷廷[1] 杨永生[1] 陈武[1] 吴成爱[1] 刘晓芳[1] 赵育芳[1] 李奕莹[1] 陈耀东 Li Tingting;Yang Yongsheng;Chen Wu;Wu Chengai;Liu Xiaofang;Zhao Yufang;Li Yiying;Chen Yaodong(Department of Ultrasonography,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院超声科,太原030001

出　　处：《中华健康管理学杂志》2023年第2期136-141,共6页Chinese Journal of Health Management

基　　金：山西省回国留学人员科研资助项目(2014-076);山西医科大学青年基金(02201425)。

摘　　要：目的探讨经直肠多模态超声及血清前列腺特异抗原(PSA)预测临床局限性前列腺癌的价值。方法本研究为横断面研究,采用2014年5月至2020年4月山西医科大学第一医院收治的可疑前列腺结节患者的临床资料,选取其中经临床及病理证实的48例临床局限性前列腺癌和51例前列腺增生为研究对象,比较两组间多模态超声特征,结合PSA,运用logistic逐步回归分析筛选出有统计学意义的指标,建立诊断模型,比较进入方程中的变量优势比(OR值),绘制受试者工作特征(ROC)曲线,评价诊断模型的预测能力。结果logistic回归分析共筛选出4个特征变量,包括增强类型、增强程度、弹性成像模式及PSA。增强程度的OR值高于其他自变量。诊断模型ROC曲线下面积为0.868(P<0.01),界值为0.514,预测临床局限性前列腺癌的灵敏度为79.2%,特异度为80.4%。结论经直肠多模态超声与血清PSA联合诊断模型对预测临床局限性前列腺癌有一定临床应用价值。Objective To explore the predictive value of transrectal multimodal ultrasound and prostate specific antigen(PSA)in clinically organ-confined prostate cancer.Methods It was a cross-sectional study.The clinical data of patients with suspected prostate nodules treated in the First Hospital of Shanxi Medical University from May 2014 to April 2020 were analyzed retrospectively.Of the patients,48 cases of clinically organ-confined prostate cancer and 51 cases of benign prostatic hyperplasia confirmed by clinical data and pathology were selected as research objects.The characteristics of transrectal multimodal ultrasound in the two groups were compared.Combined with PSA,logistic regression analysis was applied to screen the statistically significant features,and then the diagnosis model was established,and odds ratio of the variables were compared.The receiver operating characteristic(ROC)curve was constructed to analyze the predicting ability of the diagnosis model.Results Four features were obtained with logistic regression analysis finally,including enhancement type,enhancement degree,elastography mode and PSA.The odds ratio of enhancement degree was higher than those of the other independent variables.The area under ROC curve of the diagnosis model was 0.868(P<0.01),the cut-off value was 0.514.The sensitivity and specificity of the diagnosis model in predicting clinically organ-confined prostate cancer was 79.2%and 80.4%,respectively.Conclusions This combined diagnosis model of transrectal multimodal ultrasound and PSA has a certain clinical value in predicting clinically organ-confined prostate cancer.

关 键 词：前列腺肿瘤 超声检查 造影剂 弹性成像技术 

分 类 号：R737.25[医药卫生—肿瘤]