冷暴露下下丘脑调节脂肪组织褐变产热研究进展  

Research progress on hypothalamus regulates adipose tissue browning and thermogenesis under cold exposure

作　　者：韩志鹏 徐元庆[1] 苏日古嘎[1] 邢媛媛 史彬林[1] 金晓[1] HAN Zhi-peng;XU Yuan-qing;MA Sorgog;XING Yuan-yuan;SHI Bin-lin;JIN Xiao

机构地区：[1]内蒙古农业大学大学动物科学学院,内蒙古呼和浩特010018

出　　处：《饲料研究》2023年第2期126-130,共5页Feed Research

基　　金：内蒙古自治区重点研发和成果转化计划国际科技合作项目“引进肉羊运输福利标准成果示范项目(项目编号:2022YFYZ0001)”;澳大利亚昆士兰大学资助的动物福利国际合作项目“Evaluation and Improvement of Sheep Welfare duringDaily Feeding Management and Transport in Cold Weather in InnerMongolia”;农业重大技术协同推广项目“绒山羊提质增效关键技术集成推广与创新应用项目”。

摘　　要：冷暴露是导致畜禽生产力低下的应激源之一,是负责非颤抖性产热的棕色脂肪组织(BAT)和诱导性棕色脂肪(iBAT)主要生理激活因子。下丘脑是机体脂肪储存和消耗中的主要控制中心。文章综述下丘脑不同区域和神经元参与调节白色脂肪组织(WAT)褐变和BAT产热的研究进展、下丘脑通过交感神经系统作用于脂肪细胞的腺苷酸活化蛋白激酶(AMPK)信号通路、调控脂肪细胞褐变及产热机理,旨在深入了解冷暴露下畜禽产热机制,为在生产中降低其维持能量、提高生产性能和动物福利水平提供参考。Cold exposure is one of the stresses leading to low productivity in livestock.It is BAT and iBAT that are mainly responsible for non-shivering heat production.Hypothalamus is the main control center of fat storage and consumption.The paper reviews the regulation of the different regions and neurons of hypothalamus on WAT browning and BAT thermogenesis,and the regulation of hypothalamus through the action of sympathetic nervous system on the AMPK signal pathway to control adipocyte browning and thermogenesis,to deeply understand the thermogenesis mechanism of livestock under cold exposure,and to provide reference for reducing its maintenance energy and improving production performance and animal welfare.

关 键 词：脂肪组织 褐变 产热 下丘脑 冷暴露 

分 类 号：S852.2[农业科学—基础兽医学]