FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity  

作　　者：Xingzheng Li Jianlou Song Xuefeng Shi Mingyi Huang Lei Liu Guoqiang Yi Ning Yang Guiyun Xu Jiangxia Zheng 

机构地区：[1]College of Animal Science and Technology,China Agricultural University,Beijing 100193,China [2]Shenzhen Branch,Guangdong Laboratory of Lingnan Modern Agriculture,Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs,Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences,Shenzhen 518124,China.

出　　处：《Journal of Animal Science and Biotechnology》2023年第2期546-563,共18页畜牧与生物技术杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(31672408);the China Agriculture Research Systems(CARS-40);the National Key Research and Development Program of China(2021YFD1200803);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_15R62).

摘　　要：Background:Most duck eggs possess a fishy odor,indicating that ducks generally exhibit impaired trimethylamine(TMA)metabolism.TMA accumulation is responsible for this unpleasant odor,and TMA metabolism plays an essen-tial role in trimethylaminuria(TMAU),also known as fish odor syndrome.In this study,we focused on the unusual TMA metabolism mechanism in ducks,and further explored the unclear reasons leading to the debilitating TMA metabolism.Methods:To achieve this,transcriptome,proteome,and metagenome analyses were first integrated based on the constructed duck populations with high and low TMA metabolism abilities.Additionally,further experiments were conducted to validate the hypothesis regarding the limited flavin-containing monooxygenase 3(FMO3)metabolism ability of ducks.Results:The study demonstrated that liver FMO3 and cecal microbes,including Akkermansia and Mucispirillum,par-ticipated in TMA metabolism in ducks.The limited oxidation ability of FMO3 explains the weakening of TMA metabo-lism in ducks.Nevertheless,it decreases lipid deposition and increases antibacterial activity,contributing to its survival and reproduction during the evolutionary adaptation process.Conclusions:This study demonstrated the function of FMO3 and intestinal microbes in regulating TMA metabolism and illustrated the biological significance of FMO3 impairment in ducks.

关 键 词：Antibacterial Cardiovascular disease(CVD) DUCK Flavin-containing monooxygenase 3(FMO3) METAGENOME PROTEOME Transcriptome Trimethylamine(TMA) 

分 类 号：S834[农业科学—畜牧学]