Maternal organic selenium supplementation during gestation enhances muscle fiber area and muscle fiber maturation of offspring in porcine model  

作　　者：Yan Lin Hui Yan Lei Cao Daolin Mou Dajiang Ding Binting Qin Lianqiang Che Zhengfeng Fang Shengyu Xu Yong Zhuo Jian Li Jianping Wang Chao Huang Yuanfeng Zou Lixia Li De Wu Bin Feng 

机构地区：[1]Animal Nutrition Institute,Sichuan Agricultural University,Chengdu,China [2]Key Laboratory of Animal Disease‑Resistant Nutrition of Ministry of Education,Sichuan Agricultural University,Chengdu,China [3]College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,Sichuan,China

出　　处：《Journal of Animal Science and Biotechnology》2023年第2期654-665,共12页畜牧与生物技术杂志（英文版）

基　　金：supported by Fok Ying Tung Education Foundation(171019);Natural Science Foundation of Sichuan Province(2021NZZJ0016);the 111 project(D17015).

摘　　要：Background:Organic selenium supplementation during gestation improves the antioxidant status and reproduc-tive performance of sows and increases the antioxidative capacity of the intestines of their offspring.This study was conducted to investigate the effect of maternal basel diet(control)supplemented with an organic Se,2-hydroxy-4-methylselenobutanoic acid(HMSeBA),or inorganic sodium selenite(Na_(2)SeO_(3))during gestation on the antioxidant status and development of muscle in newborn and weaned piglets.Newborn piglets before colostrum intake and weaned piglets were selected for longissimus dorsi(LD)muscle collection and analysis.Results:The results showed that maternal HMSeBA supplementation increased the muscle area and content of Se in the LD muscle of newborn piglets,improved gene expression of selenoproteins,and decreased oxidative status in the LD muscle of both newborn and weaned piglets compared with the control.The expression of muscle development-related genes of newborn piglets in the HMSeBA group was lower than in the control group,whereas the expression of MRF4 in weaned piglets was higher in the HMSeBA group than in the control and Na_(2)SeO_(3)groups.In addition,HMSeBA supplementation decreased the mRNA expressions of myosin heavy chains(MyHC)IIx and MyHC IIb and the percentage of MyHC IIb;increased the expression of PGC-1αin the LD muscle of newborn piglets;increased the gene expression of MyHC IIa;and decreased the protein expression of slow MyHC and the activity of malate dehydrogenase in the LD muscle of weaned piglets compared with the control group.Conclusions:Maternal HMSeBA supplementation during gestation can improve the antioxidative capacity of the muscle of their offspring and promote the maturity of muscle fibres in weaned offspring.

关 键 词：ANTIOXIDATION HMSeBA Muscle OFFSPRING SOWS 

分 类 号：S858[农业科学—临床兽医学]