宫颈癌患者OCT4与临床病理、HPV感染及SCC-Ag水平的关系  

Relationship Between OCT4 Expression and Clinicopathology, HPV Infection and SCC-Ag Levels in Patients with Cervical Cancer

作　　者：梁艳萍 竞柏松 张琳 LIANG Yanping;JING Baisong;ZHANG Lin(Department of Gynecology,Yongcheng people’s Hospital,Shangqiu 476600,China;Department of Gynecology,Shangqiu First People’s Hospital,Shangqiu 476100,China)

机构地区：[1]永城市人民医院妇科,河南商丘476600 [2]商丘市第一人民医院妇科,河南商丘476100

出　　处：《河南医学研究》2023年第4期709-712,共4页Henan Medical Research

摘　　要：目的 研究宫颈癌中八聚体结合转录因子4(OCT4)的表达与临床病理、人乳头状瘤病毒(HPV)感染及鳞状细胞癌抗原(SCC-Ag)水平的关系。方法 选取2018年1月至2021年10月来永城市人民医院接受治疗的150例宫颈癌患者的包埋肿瘤组织标本,收集患者分期、分化、类型、淋巴结转移等信息,以免疫组织化学检测试剂盒检测OCT4,以免疫组织化学检测HPV,以化学发光免疫分析法测定试剂盒检测SCC-Ag。结果 OCT4与类型、分期、分化、淋巴结转移之间差异无统计学意义(P>0.05)。HPV感染情况不同的患者及SCC-Ag表达水平不同的患者,OCT4表达差异存在统计学意义(P<0.05)。结论 宫颈癌患者中,OCT4表达在不同临床病理中无差异,与HPV感染及SCC-Ag表达相关。Objective The relationship between octamer-bound transcription factor 4(OCT4) expression and clinicopathology, human papilloma virus(HPV) infection, and squamous cell carcinoma antigen(SCC-Ag) levels in cervical cancer was investigated.Methods A total of 150 cervical cancer patients treated in Yongcheng People’s Hospital from January 2018 to October 2021 were collected for stage, differentiation, type and lymph node metastasis. OCT4 was detected by immunohistochemistry detection kit, HPV was detected by immunohistochemistry, and SCC-Ag was detected by chemiluminescence immunoassay kit.Results There was no difference between OCT4 and type, stage, differentiation and lymph node metastasis(P>0.05). OCT4 expression varied in patients with different HPV infection conditions and patients with different SCC-Ag expression levels(P<0.05).Conclusion In cervical cancer patients, OCT4 expression was not different in different clinicopathology, and was associated with HPV infection and SCC-Ag expression.

关 键 词：宫颈癌 八聚体结合转录因子4 人乳头状瘤病毒 临床病理 鳞状细胞癌抗原 

分 类 号：R737.33[医药卫生—肿瘤]