5-氨基酮戊酸在膀胱癌的诊断和治疗中的应用  

Application of 5-aminolevulinic acid in the therapy and diagnosis of bladder cancer

作　　者：黄晓琪 刘吉成[1] Huang Xiaoqi;Liu Jicheng(Qiqihar Medical College,Qiqihar,Heilongjiang,161000,China)

机构地区：[1]齐齐哈尔医学院,黑龙江齐齐哈尔161000

出　　处：《齐齐哈尔医学院学报》2023年第4期368-372,共5页Journal of Qiqihar Medical University

摘　　要：5-氨基酮戊酸介导的光动力诊断和光动力疗法是利用光敏剂和光照射诊断和治疗疾病的方法,目前多用于膀胱癌的诊断和辅助治疗、皮肤肿瘤、某些癌前病变等。膀胱癌是泌尿系统常见的恶性肿瘤,其具有多中心发病、常伴发原位癌、治疗后易复发、复发后肿瘤恶性程度提高的特点。早期诊断、个体化治疗并加强随访对改善患者预后具有十分重要的意义。本文总结了5-氨基酮戊酸光动力诊断和光动力疗法在体内外条件下对膀胱癌的作用。5-aminolevulinic acid mediated photodynamic diagnosis(PDD)and 5-aminolevulinic acid mediated photodynamic therapy(PDT)are methods of diagnosing and treating diseases using photosensitizers and light irradiation.Currently,they are mostly used in the diagnosis and adjuvant therapy of bladder cancer,skin tumors,and certain precancerous lesions.Bladder cancer is a common malignant tumor of the urinary system,which has the characteristics of multi-center onset,often accompanied by carcinoma in situ,easy recurrence after treatment,and increased tumor malignancy after recurrence.Early diagnosis,individualized treatment and enhanced follow-up are of great significance to improve the prognosis of patients.This article summarizes the effects of 5-aminolevulinic acid photodynamic diagnosis and photodynamic therapy on bladder cancer in vitro and in vivo.

关 键 词：5-氨基酮戊酸 膀胱癌 光动力诊断 光动力治疗 

分 类 号：R737.14[医药卫生—肿瘤]