ALBI和PALBI分级在乙肝相关性肝细胞癌病人预后评估中的价值  

The value of ALBI and PALBI grades in the prognostic assessment of hepatitis B virus associated HCC patients

作　　者：范龙飞 吴斌全[1] 庞青 汪鹿瑶 潘华东 王春芳 刘会春[1] 谈燚[1] FAN Long-fei;WU Bin-quan;PANG Qing;WANG Lu-yao;PANG Hua-dong;WANG Chun-fang;LIU Hui-chun;TAN Yi(Department of Hepatobiliary Surgery,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院肝胆外科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2023年第3期330-334,共5页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究重点项目(KJ2018ZD022);蚌埠医学院自然科学研究重点项目(BYKY1858ZD);国家级大学生创新创业训练项目(201910367053)。

摘　　要：目的:探讨白蛋白-胆红素(ALBI)和血小板-白蛋白-胆红素(PALBI)分级在Child-Pugh A级肝细胞癌(HCC)病人预后评估中的价值。方法:行根治性手术的Child-Pugh A级乙肝相关性HCC病人134例,根据术前血清学检查结果计算ALBI和PALBI分级,采用Kaplan-Meier曲线和Cox回归分析评估病人总生存期(OS)和无复发生存期(RFS)。结果:经随访,病死37例,复发35例。Kaplan-Meier分析结果显示,ALBI、PALBI分级与OS和RFS均具有相关关系(P<0.05)。多因素分析显示,ALBI和PALBI分级均为病人独立的预后模型。不同评分系统间,PLABI+肿瘤直径、ALBI+肿瘤直径、ALBI+意大利肝癌小组评分(CLIP)较单独的CLIP、PLABI、ALBI、终末期肝癌模型评分、巴塞罗那分期在预后预测能力方面更具有意义。结论:ALBI和PALBI分级是评估Child-Pugh A级HCC病人预后有价值的模型,如结合肿瘤直径,PALBI较ALBI分级有更好的预后价值。Objective:To explore the value of albumin-bilirubin(ALBI)and platelet-albumin-bilirubin(PALBI)grades in the prognostic evaluation of Child-Pugh grade A HCC patients.Methods:Clinical data of 134 Child-Pugh grade A hepatitis B virus associated HCC patients undergoing radical resection were retrospectively analyzed.ALBI and PALBI grades were calculated based on preoperative serologic examination.Overall survival(OS)and recurrence-free survival(RFS)were estimated using Kaplan-Meier curves and Cox regression.Results:After follow-up,37 patients died and 35 patients relapsed.Kaplan-Meier analysis showed that ALBI and PALBI grades were significantly correlated with OS and RFS(P<0.05).Multivariate analysis indicated that both ALBI and PALBI grades were independent prognostic models for patients.Among different scoring systems,PLABI+tumor diameter,ALBI+tumor diameter,and ALBI+Italian liver cancer group score(CLIP)were more significant in predicting prognosis than CLIP,PLABI,ALBI,end-stage liver cancer model score,and Barcelona staging alone.Conclusions:ALBI[6]NAZARPOUR S,RAMEZANI TF,SIMBAR M,et al.Thyroid dysfunction and pregnancy outcomes and PALBI grades are valuable models for evaluating the prognosis of Child-Pugh grade A HCC patients,if when they combine with tumor diameter,PALBI grade has better prognostic value for HCC patients than ALBI grade.

关 键 词：肝细胞肿瘤 白蛋白-胆红素分级 血小板-白蛋白-胆红素分级 预后 

分 类 号：R735.7[医药卫生—肿瘤]