探讨丁苯酞软胶囊联合常规疗法对改善卒中后认知 障碍的有效性及安全性  

Explore the efficacy and safety of butylphthalide soft capsule combined with conventional therapy in improving cognitive impairment after stroke

作　　者：姚建鹏 曾繁鑫 韩巧琳[1] 吴惜燕[1] Yao Jianpeng;Zeng Fanxin;Han Qiaolin;Wu Xiyan(The second ward of department of neurology,Jieyang people's hospital,Jieyang,Guangdong,522000,China)

机构地区：[1]揭阳市人民医院神经内科二区,广东揭阳522000

出　　处：《齐齐哈尔医学院学报》2023年第3期219-223,共5页Journal of Qiqihar Medical University

摘　　要：目的探讨丁苯酞软胶囊联合常规疗法治疗缺血性卒中后认知障碍的疗效分析。方法选择2018年7月—2020年12月本院收治的120例缺血性卒中后血管性认知障碍患者作为研究对象,按信封随机法分为实验组和参照组两组,每组各60例。参照组予以常规疗法,实验组在此基础上予以丁苯酞软胶囊治疗,比较两组治疗有效合计率、MoCA评分数值、ADL评分数值、FMA评分数值、治疗效果满意率与不良反应率。结果实验组治疗有效率为93.33%,高于参照组的80.00%,差异有统计学意义(P<0.05)。两组治疗前MoCA、ADL评分和FMA评分比较差异无统计学意义(P>0.05);两组治疗1个月、3个月、6个月后的MoCA评分、ADL评分和FMA评分上升,且实验组MoCA评分、ADL评分和FMA评分高于参照组,差异存在统计学意义(P<0.05)。实验组治疗效果满意率为95.00%,高于参照组的81.67%,差异存在统计学意义(P<0.05)。实验组恶心、一过性转氨酶升高与腹部不适不良反应发生率为10.00%,与参照组的6.67%比较,差异无统计学意义(P>0.05)。结论对缺血性卒中后认知障碍患者给予丁苯酞软胶囊结合常规疗法的疗效显著,有利于提高神经功能,改善其生活能力,且安全性良好,值得推广。Objective To explore the efficacy of butylphthalide soft capsule combined with conventional therapy in the treatment of cognitive impairment after stroke.Methods A total of 120 patients with post-stroke vascular cognitive impairment,those who were admitted to and treated in our hospital from July 2018 to December 2020,were selected as study subjects.According to envelope random method they were randomly divided into experimental group and control group,60 cases in each group.The control group was given conventional therapy,and the experimental group was given butylphthalide soft capsules on this basis.The total effective rate,MoCA score,ADL score,FMA score,total satisfaction rate of treatment effect and total adverse reaction rate were compared between the two groups.Results The total effective rate of the experimental group was 93.33%,and it was higher than 80.00%of the reference group,the difference was statistically significant(P<0.05).There were no significant difference in montreal cognitive assessment,ADL and FMA scores between the two groups before treatment(P>0.05).The montreal cognitive assessment score,ADL score and FMA score of the two groups increased after 1 month,3 months and 6 months of treatment,and the montreal cognitive assessment score,ADL score and FMA score of the experimental group were higher than those of the reference group group,the differences were statistically significant(P<0.05).The total satisfaction rate of the experimental group was 95.00%,and it was higher than 81.67%of the reference group,with a significant difference(P<0.05).The incidence of nausea,transient elevation of transaminase and abdominal discomfort in the experimental group was 10.00%,compared with 6.67%in the reference group,and there was no significant difference(P>0.05).Conclusions Butylphthalide soft capsule combined with conventional therapy has significant curative effect on post-stroke cognitive impairment patients.It is beneficial to improve neurological function,improve their living ability,and has good safet

关 键 词：缺血性卒中 丁苯酞 认知障碍 不良反应 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]