多巴胺系统多基因与青少年攻击行为的U型关系:母亲消极教养的调节作用  

The U-shaped relationship between dopaminergic genes and adolescent aggressive behavior:The moderating role of maternal negative parenting

作　　者：林小楠 曹衍淼[1] 张文新[1] 纪林芹[1] LIN Xiaonan;CAO Yanmiao;ZHANG Wenxin;JI Linqin(School of Psychology,Shandong Normal University,Shandong Provincial Institute of Student Development and Mental Health,Jinan 250014,China)

机构地区：[1]山东师范大学心理学院,山东省学生发展与心理健康研究院,济南250014

出　　处：《心理学报》2023年第4期588-599,I0002-I0004,共15页Acta Psychologica Sinica

基　　金：国家自然科学基金项目(32071073,31900776,31971008);山东省自然科学基金项目(ZR2019MC025)。

摘　　要：多巴胺活性与攻击相关的脑功能活动呈倒U型关系。本研究对1044名汉族青少年(初次测评时M age=13.32±0.49岁,50.2%女生)的攻击行为进行间隔一年的两次测评,采用多基因累积分范式考察多巴胺系统的多基因功能积分与青少年攻击行为间的关系以及母亲消极教养的调节作用。结果发现,多巴胺系统多基因累积分二次项与母亲消极教养交互影响两个时间点的青少年攻击行为:在较高母亲消极教养条件下,携带较多或较少低多巴胺活性相关等位基因的青少年表现出高水平的攻击行为,呈U型关系;在较低母亲消极教养条件下,多基因累积分二次项与青少年的攻击行为关系不显著。本研究为多巴胺系统基因的联合效应与母亲消极教养调节青少年攻击行为的基因作用机制提供证据。Dopaminergic genes have been frequently found to be associated with aggressive behavior,but the results are inconsistent.One reason for the inconsistencies is there might be the U-shaped relationship between dopaminergic genetic variants and aggressive behavior.More specifically,evidence has suggested an inverted U-shaped relationship between dopamine activity and prefrontal cortex(PFC)function(a critical region related to aggression),with both dopaminergic hypofunction and hyperfunction,were related to poor PFC function.It is possible that the relationship between dopaminergic genes and aggression approximates a U-shaped function.However,such U-shaped relationship is rarely investigated in previous studies.Moreover,several concerns have been raised about the ignoring the polygenic traits of aggressive behavior when conducting gene by environment interaction(G×E)research using single loci.Therefore,the present study aimed to examine the interaction between dopaminergic genetic variants and maternal negative parenting on adolescent aggressive behavior by adopting the approach of multilocus genetic profile score(MGPS).Participants were 1044 adolescents(mean age 13.32±0.49 years old at Time 1,50.2%females)recruited from the community.The adolescents completed two assessments with an interval of one year.Saliva samples,mother-reported parenting data and data on peer-nominated aggressive behavior were collected.All measures showed good reliability.The MGPS was created by COMT rs4680 polymorphisms,DRD2 rs1799978 polymorphisms and DAT1 rs27072 polymorphisms.Genotyping in three dopaminergic genes were performed for each participant in real time with MassARRAY RT software version 3.0.0.4 and analyzed using the MassARRAY Typer software version 3.4(Sequenom).To examine whether negative parenting moderates the effects of MGPS on adolescent aggressive behavior,hierarchical regression analyses were conducted.The results found that after controlling for gender,maternal negative parenting was a significant risk factor for adol

关 键 词：攻击行为 母亲消极教养 多巴胺系统 多基因累积分 U型关系 

分 类 号：B844[哲学宗教—发展与教育心理学] B845[哲学宗教—心理学]