培元解毒通络汤治疗原发性肝癌经肝动脉化疗栓塞术术后综合征临床研究  

Effect of Self-made Peiyuan Jiedu Tongluo Decoction on postoperative syndrome in primary liver cancer after a transcatheter arterial chemoembolization

作　　者：张凇铭 葛源森 张伟 史晓雯 葛小栋 王清贤 ZHANG Songming;GE Yuansen;ZHANG Wei;SHI Xiaowen;GE Xiaodong;WANG Qingxian(Oncology,Tangshan Hospital of Traditional Chinese Medicine,Tangshan,Hebei 063000;Geriatrics,Tangshan Hospital of Traditional Chinese Medicine,Tangshan,Hebei 063000;Anorectal Department,Tangshan Hospital of Traditional Chinese Medicine,Tangshan,Hebei 063000)

机构地区：[1]河北省唐山市中医医院肿瘤科,河北唐山063000 [2]河北省唐山市中医医院老年病科,河北唐山063000 [3]河北省唐山市中医医院肛肠科,河北唐山063000

出　　处：《河北中医》2023年第3期369-371,376,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2020年度中医药类科研计划课题(编号:2020392)。

摘　　要：目的观察培元解毒通络汤治疗原发性肝癌经肝动脉化疗栓塞术(TACE)术后综合征的临床疗效。方法将92例原发性肝癌TACE术后综合征患者采用随机数字表法等分抽取分为2组,对照组46例予以西医常规对症治疗,治疗组46例在对照组治疗基础上加培元解毒通络汤,2组均治疗7天后统计疗效。比较2组治疗后发热、恶心呕吐、肝区疼痛阳性率,治疗前后Kamofsky功能状态(KPS)评分及肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBiL)、γ-谷氨酰转移酶(GGT)水平。结果治疗组治疗后临床症状阳性率为4.35%(2/46),低于对照组的17.39%(8/46)(P<0.05)。治疗后,2组KPS评分均较本组治疗前升高(P<0.05),且治疗组高于对照组(P<0.05)。治疗后,2组肝功能指标AST、ALT、TBiL及GGT水平均较本组治疗前降低(P<0.05),且治疗组均低于对照组(P<0.05)。治疗组总有效率95.65%(44/46),高于对照组的78.26%(36/46)(P<0.05)。结论培元解毒通络汤治疗原发性肝癌TACE术后综合征可改善患者临床症状,减轻肝功能损伤,提高患者生活质量。Objective To investigate the effect of self-made Peiyuan Jiedu Tongluo Decoction on postoperative syndrome in primary liver cancer(PLC)after transcatheter arterial chemoembolization(TACE).Methods Totally 92 PLC patients with TACE were enrolled as study samples.A total of 92 PLC patients with TACE were randomly assignedin 1∶1 ratio to two groups.The patients in the treatment group were treated with conventional Western medicine+Peiyuan Jiedu Tongluo Decoction,while the control group with the former only.The positive rates(fever,nausea and vomiting,liver pain),Karnofsky performance status(KPS)score,liver function indexes(alanine aminotransferase[ALT]aspartate aminotransferase[AST],total bilirubin[TBiL]),as well asγ-glutamyltransferase(GGT)were included as comparisons.Results After treatment,the positive rate of clinical symptoms in the study group was less than that in the control group(4.35%[2/46]vs 17.39%[8/46],P<0.05).KPS scores in groups were higher(P<0.05),and the treatment group was higher than the control group(P<0.05).AST,ALT,TBiL and GGT in groups were lower(P<0.05),and the treatment group was more prevalent relative to the control group(P<0.05).The total effective rate of the treatment group was higher than that of the control group(95.65%[44/46]vs 78.26%[36/46],P<0.05).Conclusion For PLC patients with TACE,self-made Peiyuan Jiedu Tongluo Decoction can improve the clinical symptoms,prevent the recurrence,reduce damage of liver function,and improve the quality of life of patients.

关 键 词：癌 肝细胞 化学栓塞 治疗性 中医治疗学 

分 类 号：R735.705.31[医药卫生—肿瘤]