宫颈上皮内瘤变患者宫颈锥切术后发生高危型HPV持续感染的影响因素分析  

Analysis of influencing factors of high-risk HPV persistent infection in patients with cervical intraepithelial neoplasia after cervical conization

作　　者：赵慧芳 张凤格 朱丹 倪琴 Zhao Huifang;Zhang Fengge;Zhu Dan;Ni Qin(Shunyi Maternal and Child Health Hospital(Shunyi Women's and Children's Hospital of Beijing Children's Hospital),Beijing 101300,China)

机构地区：[1]顺义区妇幼保健院(北京儿童医院顺义妇儿医院)妇科,北京101300

出　　处：《实用妇科内分泌电子杂志》2022年第29期9-12,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨宫颈上皮内瘤变(CIN)患者宫颈锥切术(CKC)后发生高危型人乳头瘤病毒(HR-HPV)持续感染的影响因素。方法回顾性分析本院200例接受CKC治疗的CINⅡ~Ⅲ伴HR-HPV感染患者临床资料。收集患者病情相关资料,建立Logistic回归模型分析CINⅡ~Ⅲ患者CKC术后HR-HPV持续感染的影响因素。结果200例CINⅡ~Ⅲ患者CKC术后6个月持续感染患者共38例,HR-HPV持续感染率19.00%(38/200)。Logistic回归模型显示,CIN分级Ⅲ级(OR=1.793,95%CI:1.284,2.467)、HPV 18感染(OR=1.853,95%CI:1.380,2.633)、HPV16感染(OR=1.926,95%CI:1.379,2.453)、多重HR-HPV感染(OR=2.535,95%CI:2.990,4.560)是CIN患者CKC术后HR-HPV持续感染的危险因素。结论CKC治疗CINⅡ~Ⅲ患者术后具有较高的HR-HPV持续感染风险,而CIN分级高、HPV18感染、HPV16感染、多重HR-HPV感染是CINⅡ~Ⅲ患者CKC术后HR-HPV持续感染的危险因素。Objective To investigate the factors affecting the persistence of high-risk human papillomavirus(HR-HPV)infection in patients with cervical intraepithelial neoplasia(CIN)after cervical conectomy(CKC).Methods The clinical data of 200 patients treated with CKC with HR-HPV infection were retrospectively analyzed.The relevant data of the patients were collected,and the Logistic regression model was established to analyze the infl uencing factors of persistent HR-HPV infection in CINⅡ~Ⅲ patients after CKC surgery.Results There were 38 cases of persistent infection 6 months after CKC operation in 200 patients with CINⅡ~Ⅲ,and the persistent HR-HPV infection rate was 19.00%(38/200).Logistic regression model showed that CIN gradeⅢ(OR=1.793,95%CI:1.284,2.467),HPV 18 infection(OR=1.853,95%CI:1.380,2.633),HPV16 infection(OR=1.926,95%CI:1.379,2.453)and multiple HR-HPV infection(OR=2.535,95%CI:2.990,4.560)were risk factors for persistent HR-HPV infection after CKC in CIN patients.Conclusion CKC has a high risk of HR-HPV persistent infection after the treatment of CINⅡ~Ⅲ,and high CIN grade,HPV 18 infection,HPV 16 infection,multiple HR-HPV infection are the risk factors of HR-HPV persistent infection after the treatment of CINⅡ~Ⅲ.

关 键 词：宫颈上皮内瘤变 宫颈锥切术 高危型人乳头瘤病毒 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]