子宫内膜癌不同病理类型的PR、ER、C-erbB-2表达水平及其临床意义  

Expression of PR,ER,C-erbB-2 in endometrial carcinoma of different pathological types and its clinical significance

作　　者：罗红霞[1] 钟思敏 李科 Luo Hongxia;Zhong Simin;Li Xe(Department of Pathology,Beihai People's Hospital,Beihai 536000,China;Guangxi Medical University Ruigu Medical Laboratory Co.,LTD.,Nanning 530000,China)

机构地区：[1]北海市人民医院病理科,广西北海536000 [2]广西医大睿谷医学检验有限公司,广西南宁530000

出　　处：《实用妇科内分泌电子杂志》2022年第28期11-14,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探究子宫内膜癌不同病理类型的雌激素受体(ER)、孕激素受体(PR)及原癌基因(C-erbB-2)表达水平及其临床意义。方法选取80例子宫内膜癌患者为子宫内膜癌组;另选取同期正常子宫内膜30例作为正常子宫内膜组,非典型增生子宫内膜30例作为非典型增生子宫内膜组。对比三组PR、ER、C-erbB-2的表达水平及子宫内膜癌患者在不同病理分期、分化程度、病理类型中PR、ER、C-erbB-2表达水平。结果子宫内膜癌组、非典型增生子宫内膜组、正常子宫内膜组的ER阳性率分别为58.75%,80.00%.93.33%,比较差异有统计学意义(P<0.05);子宫内膜癌组、非典型增生子宫内膜组、正常子宫内膜组PR阳性率分别为56.25%、76.67%,90.00%,比较差异有统计学意义(P<0.05);子宫内膜癌组C-erbB-2阳性率高于非典型增生子宫内膜组、正常子宫内膜组,差异有统计学意义(P<0.05)。子宫内膜癌患者中病理分期越高,ER、PR的阳性率越低(P<0.05);病理分化程度越高,子宫内膜癌患者ER、PR的阳性率越高(P<0.05)。子宫内膜癌患者C-erbB-2在病理分期中呈正向增长,分期越高,C-erbB-2阳性率越高(P<0.05);分化程度越低,子宫内膜癌患者C-erbB-2阳性率越高(P<0.05)。子宫内膜样腺癌的ER阳性率、PR阳性率及C-erbB-2阳性率均高于子宫内膜腺癌、浆液性腺癌,差异具有统计学意义(P<0.05)。结论子宫内膜癌患者PR、ER、C-erbB-2表达水平与临床病理密切相关,根据三者的表达水平,判断患者病情的恶性程度,对指导患者预后治疗有一定临床价值。Objective To explore the expression levels of estrogen receptor(ER),progesterone receptor(PR)and protooncogene(C-erbB-2)in different pathological types of endometrial cancer and their clinical significance.Methods 80 patients with endometrial cancer were selected as endometrial cancer group.In addition,30 cases of normal endometrium and 30 cases of atypical endometrium were selected as normal endometrium group and atypical endometrium group.The expression levels of PR,ER and C-erbB-2 in the three groups and the expression levels of PR,ER and C-erbB-2 in patients with endometrial cancer in different pathological stages,degrees of differentiation and pathological types were compared.Results The positive rates of ER in endometrial cancer group,atypical hyperplasia endometrial group and normal endometrial group were 58.75%,80.00% and 93.33%,respectively,and the difference was statistically significant(P<0.05).The positive rates of PR in endometrial carcinoma group,atypical hyperplasia endometrial group and normal endometrial group were 56.25%,76.67%and 90.00%,respectively,and the diflerence was statistically significant(P<0.05).The positive rate of C-erbB-2 in endometrial carcinoma group was higher than that in atypical hyperplasia endometrial group and normal endometrial group,the difference was statistically significant(P<0.05).The higher the pathological stage was,the lower the positive rates of ER and PR were(P<0.05).The higher the degree of pathological difFerentiation,the higher the positive rate of ER and PR in endometrial cancer patients(P<0.05).In patients with endometrial cancer,the positive rate of C-erbB-2 increased in the pathological stage,and the higher the stage,the higher the positive rate of C-erbB-2 was(P<0.05).The lower the differentiation degree,the higher the positive rate of C-erbB-2 in endometrial cancer patients(P<0.05).The positive rates of ER,PR and C-erbB-2 in endometrial adenocarcinoma were higher than those in endometrial adenocarcinoma and serous adenocarcinoma,and the differences were

关 键 词：雌激素受体 孕激素受体 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]