牙周微创外科技术联合CGF屏障膜应用于组织再生中的临床效果评价  

Clinical effect evaluation of minimally invasive periodontal surgery combined with CGF barrier membrane in tissue regeneration

作　　者：周占豪 笪海芹[1,2,3] 傅俊博 韩爽[3] 陈莹[3] ZHOU Zhan-hao;DA Hai-qin;FU Jun-bo;HAN Shuang;CHEN Ying(Hefei School of Stomatology,Anhui Medical University,Anhui Hefei 230001,China;The Fifth Clinical College,Anhui Medical University,Anhui Hefei 230001,China;Hefei School of Stomatology,Anhui Hefei 230001,China)

机构地区：[1]安徽医科大学合肥口腔临床学院,安徽合肥230001 [2]安徽医科大学第五临床医学院,安徽合肥230001 [3]合肥市口腔医院,安徽合肥230001

出　　处：《临床口腔医学杂志》2023年第2期107-111,共5页Journal of Clinical Stomatology

基　　金：2021年合肥市关键共性技术研发和重大科技成果工程化立项项目(2021YL008);2022年安徽省重点研究与开发计划项目(2022e07020059);安徽医科大学校科研基金资助(2022xkj255)。

摘　　要：目的:通过临床和CBCT指标评价微创外科技术(minimally invasive surgical technique, MIST)与浓缩生长因子(concentrated growth factors, CGF)屏障膜二者结合应用于牙周组织再生的治疗效果。方法:筛选符合条件的患者,随机分成采用MIST联合CGF膜治疗的实验组(骨缺损区覆盖CGF膜)与采用引导组织再生术治疗的对照组(骨缺损区覆盖胶原膜)。比较两组患牙术前与术后6个月临床及CBCT指标;并在术后第2天、第4天进行回访,评估患者术区的疼痛与肿胀情况。结果:术前,比较实验组与对照组组间各项临床及CBCT指标,差异均无统计学意义(P>0.05)。术后6个月,两组探诊深度、牙龈退缩深度、临床附着丧失和CBCT骨缺损深度均较于术前有明显变化,差异有统计学意义(P<0.05);术后6个月,实验组牙龈退缩深度小于对照组(P<0.05);两组组间探诊深度、临床附着丧失和CBCT骨缺损深度比较差异均无统计学意义(P>0.05)。实验组患者术后第2天术区肿胀VAS评分低于对照组,差异有统计学意义(P<0.05)。结论:微创外科技术联合CGF屏障膜能显著改善牙周炎垂直型骨缺损患牙的牙周探诊深度和临床附着水平,具有良好的骨再生效果,获得更少的牙龈退缩,并能减轻患者术后的肿胀不适。Objective:Clinical indicators and indicators on CBCT were used to observe the clinical effect of combined application of minimally invasive surgical technique(MIST)and concentrated growth factors(CGF)barrier membrane in periodontal tissue regeneration.Methods:According to the study criteria, the selected patients were randomly divided into experimental group(bone defect area covered with CGF membrane)treated with MIST combined with CGF membrane and control group(bone defect area covered with collagen membrane)treated with guided tissue regeneration(GTR).The clinical indicators and indicators on CBCT of the two groups were compared before operation and 6 months after operation.The patients were followed up 2 and 4 days after operation to assess the pain and swelling of the operation area.Results:Before operation, the difference in clinical indicators and indicators on CBCT between the two groups was not significant statistically(P>0.05).At 6 months after operation, probing depth, gingival recession depth, clinical attachment loss, and depth of bone defect on CBCT in the two groups had significant changes compared with those before operation(P<0.05).At 6 months after operation, the experimental group had less gingival recession depth than the control group and the difference was statistically significant(P<0.05).At 6 months after operation, there were no significant differences in probing depth, clinical attachment loss and depth of bone defect on CBCT between the two groups(P>0.05).In terms of surgical complications, the VAS score of postoperative swelling in the experimental group on the second day after operation was lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion:Minimally invasive surgical technique combined with CGF barrier membrane can significantly improve the depth of probing and clinical attachment level of teeth with vertical bone defects in periodontitis, and has good bone regeneration effect, less gingival recession, and can reduce postoperative

关 键 词：浓缩生长因子 微创外科技术 牙周组织再生 慢性牙周炎 

分 类 号：R781.4[医药卫生—口腔医学]