序贯与同步放化疗治疗复发性直肠癌的效果  

Effect of sequential and synchronous chemoradiotherapy in the treatment of recurrent rectal cancer

作　　者：杨曼 李国文 YANG Man;LI Guo-wen(Department of 3rd Oncology,Chaozhou People's Hospital,Chaozhou Guangdong Province 521000,China)

机构地区：[1]潮州市人民医院肿瘤三科,广东潮州521000

出　　处：《中国城乡企业卫生》2023年第2期134-136,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的 分析在进行复发性直肠癌的治疗过程中,应用序贯与同步放化疗效果的差异。方法 本次研究随机抽取2019年8月—2020年8月潮州市人民医院接诊的76例复发性直肠癌患者,按照电脑排序均分为研究组和参照组各38例。其中,治疗过程中接受序贯放化疗的为参照组,接受同步放化疗治疗的为研究组。比较不同方案的治疗用时、治疗有效性及不良反应发生情况。结果 研究组患者治疗有效率为84.21%,高于参照组的63.16%,差异有统计学意义(χ^(2)=4.343,P<0.05)。研究组患者治疗后呕吐、腹泻、蛋白尿及白细胞下降;发生率均稍高,但组间数据比较差异无统计学意义(P>0.05)。研究组患者治疗的用时为(41.07±2.36)d,低于参照组的(60.54±1.88)d,差异有统计学意义(P<0.05)。结论 在对复发性直肠癌患者进行治疗的过程中,采取同步放化疗治疗能够起到良好的效果,有效控制患者的病情进展,改善临床症状和生活质量,虽然不良反应发生对序贯治疗稍显上升,但患者可耐受,且经该治疗方案的用时更短,因此适合于临床中应用。Objective To analyze the effect difference of sequential and synchronous radiotherapy and chemotherapy in the treatment of recurrent rectal cancer. Methods A total of 76 patients with recurrent rectal cancer treated in Chaozhou People’s Hospital from August 2019 to August 2020 were randomly selected for this study. They were divided into two groups according to computer sequencing,with 38 cases in each group. Those who received sequential radiotherapy and chemotherapy during the treatment were the reference group and those who received synchronous radiotherapy and chemotherapy were the study group.The treatment time,treatment effectiveness and toxic and side effects under different schemes were compared. Results The effective rate of treatment in the study group was 84.21%,which was higher than63.16% in the reference group,and the difference was statistically significant (χ^(2)=4.343,P<0.05). The occurrence rate o f vomiting,diarrhea,proteinuria and leukopenia in the study group was slightly higher after treatment,but there was no significant difference in the data between the groups(P >0.05). The treatment time of the study group was(41.07 ±2.36) d,which was lower than(60.54 ±1.88) d of the reference group,and the difference was statistically significant(P<0.05). Conclusion In the treatment of patients with recurrent rectal cancer,synchronous radiotherapy and chemotherapy could play a good effect,effectively control the progress of patients,and improve their clinical symptoms and quality of life.Although its toxicity and side effects were slightly increased for sequential treatment,patients could tolerate it,and the treatment time was shorter,so it was suitable for clinical application.

关 键 词：复发性直肠癌 序贯放化疗治疗 同步放化疗治疗 

分 类 号：R735.1[医药卫生—肿瘤]