富血小板纤维蛋白膜联合西帕依固龈液治疗中度牙周炎的疗效分析  

Therapeutic effect of autologous blood platelet-rich fibrin membrane combined with Xipayi mouth rinse in treatment of moderate periodontitis

作　　者：闫磊[1] 杨欣 赵娟 孙巍 冯雪莲[3] YAN Lei;YANG Xin;ZHAO Juan;SUN Wei;FENG Xuelian(Department of Oral and Maxillofacial Surgery,General Hospital of Xinjiang Military Region,Urumqi 830000,China;Department of Orthopedic Trauma,General Hospital of Xinjiang Military Region,Urumqi 830000,China;Department of Hematology,General Hospital of Xinjiang Military Region,Urumqi 830000,China)

机构地区：[1]新疆军区总医院口腔颌面外科,乌鲁木齐830000 [2]新疆军区总医院创伤骨科,乌鲁木齐830000 [3]新疆军区总医院血液科,乌鲁木齐830000

出　　处：《新疆医科大学学报》2023年第2期206-209,共4页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金面上项目(2021D01C474)。

摘　　要：目的研究富血小板纤维蛋白膜(Platelet rich fibrin,PRF)联合西帕依固龈液治疗中度牙周炎的疗效。方法以2021年8月-2022年6月新疆军区总医院口腔颌面外科(口腔门诊)就诊的91名中度牙周炎的患者为研究对象,随机分为试验组(47人)和对照组(44人)。对照组采用常规牙周基础治疗结合西帕依固龈液含漱。试验组在对照组基础上,联合PRF治疗,术后1个月复查,比较两组治疗前后有效率、牙龈出血指数(Sulcus bleeding index,SBI)、菌斑指数(Plaque index,PLI)、附着丧失指数(Loss of attachment,AL)、探诊深度(Probing depth,PD),采用ELISA法检测炎性因子水平白细胞介素(IL)-1β、IL-8、IL-10。结果与对照组比较,试验组治疗后总有效率升高,牙周SBI、PLI、AL,PD水平均降低,牙龈沟液中IL-1β、IL-8、IL-10水平均下降,差异均有统计学意义(P<0.05)。结论PRF联合西帕依固龈液治疗中度牙周炎效果显著,值得临床推广。ObjectiveAnalysis of the efficacy of autologous blood platelet-rich fibrin membrane combined with Uyghur medicine Xipayi mouth rinse in treatment of moderate periodontitis.MethodsA total of 91 patients with moderate periodontitis who visited in the hospital from August 2021 to June 2022 were selected as the research objects.The subjects were randomly divided into the experimental group(47 people)and the control group(44 people).The control group was treated with conventional periodontal basic therapy and Xipayi mouth rinse.On the basis of the control group,the experimental group was treated with autologous blood platelet-rich fibrin membrane,and the patients were re-examined 1 month after the operation to compare effective rate,sulcus bleeding index,plaque index,loss of attachment,probing depth and ELISA between the two groups before and after the treatment Interleukin(IL)-1β,IL-8 and IL-10 were detected by the method.ResultsCompared with the control group,the total effective rate of the test group increased after treatment,and the levels of periodontal SBI,PLI,AL,PD decreased,and IL-1 in gingival crevicular fluidβ,the levels of IL-8 and IL-10 decreased significantly(P<0.05).ConclusionAutologous platelet-rich fibrin membrane combined with Uyghur medicine Xipayi mouth rinse has a significant effect on periodontitis,and it is worthy of clinical promotion.

关 键 词：富血小板纤维蛋白膜 西帕依固龈液 牙周炎 

分 类 号：R780.1[医药卫生—口腔医学]