外泌体微小RNA-130a在非肿瘤性疾病中的研究进展  

Research progress on exosome-microRNA-130a in non-neoplastic diseases

作　　者：周涛[1] 高鲁方[1] 冯超[1] 杨列红 曲昊楠 杨富瑜 高士豪 Zhou Tao;Gao Lufang;Feng Chao;Yang Liehong;Qu Haonan;Yang Fuyu;Gao Shihao(Department of Cardiac Surgery,Guizhou Provincial People’s Hospital,Guiyang 550002,China)

机构地区：[1]贵州省人民医院心外科,贵阳550002

出　　处：《中华实验外科杂志》2023年第1期182-186,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81960050、82160056);贵州省自然基金项目(黔科合基础[2020]1Y293);贵州省卫生健康委员会科学技术基金(gzwkj2021-193);贵州省人民医院2019年度国家自然科学基金后补助基金(GPPH-NSFC-2019-24)。

摘　　要：外泌体广泛存在于细胞外微环境和各种体液中,可通过传递微小RNA(miR)、mRNA和蛋白质等信号分子介导信号转导。miR-130a可作为细胞间信号传递的重要物质存在于某些病理生理过程中的外泌体中,参与各种疾病的调控机制,成为某些疾病的潜在标志物和治疗靶点。现综述外泌体miR-130a在非肿瘤性疾病中的作用和调控机制。Exosomes widely exist in the extracellular microenvironment and various body fluids,and can mediate signal transduction between organs,tissues and cells by passing mRNA,protein and microRNA(miR).MiR-130a can be an important substance for intercellular signal transmission,which exists in the exosomes of some pathophysiological processes and participates in the regulation mechanism of various diseases.Exo-miR-130a can be a potential marker and therapeutic target of some diseases.This article reviews the role and regulatory mechanism of Exo-miR-130a in non-neoplastic diseases.

关 键 词：外泌体 微小RNA 调控机制 

分 类 号：R363[医药卫生—病理学]