不同粒径珍珠粉透皮吸收的研究  

Transdermal Absorption of Pearl Powder with Different Partical Size

作　　者：童银洪[1] 刘永[1] 纪德安 肖松丰 高平 TONG Yinhong;LIU Yong;JI Dean;XIAO Songfeng;GAO Ping(Pearl Research Institute,Guangdong Ocean University,Zhanjiang,Guangdong 524025,China;Pearl Co.,Ltd.of Zhanjiang Ocean University,Zhanjiang,Guangdong 524025,China;Zhanjiang Institute for Food and Drug Control,Zhanjiang,Guangdong 524022,China)

机构地区：[1]广东海洋大学珍珠研究所,广东湛江524025 [2]湛江海洋大学珍珠有限公司,广东湛江524025 [3]湛江市食品药品检验所,广东湛江524022

出　　处：《农业研究与应用》2022年第6期10-16,共7页Agricultural Research and Application

基　　金：2020年度湛江市科技计划项目“企鹅珍珠贝三型珍珠培育技术研究与产业化”(2020A01006)。

摘　　要：采用扫描电镜、X-粉末衍射和红外光谱研究了平均粒径为0.3μm、3μm和10μm的三种珍珠粉的粒径分布和矿物组成;采用KM小鼠皮肤为实验屏障,以TP-6智能透皮试验仪建立透皮吸收实验方法,采用紫外可见分光光度计测定钙离子含量,比较三种珍珠粉的钙离子透皮速率和24小时累计渗透量。结果表明:0.3μm珍珠粉存在团聚,3μm珍珠粉粒径均匀,10μm珍珠粉粒径差别大;三种珍珠粉的矿物组成主要为文石;透皮速率分别为0.0055、0.0089和0.0010 mg·cm^(-2)·h^(-1),24小时累计渗透量分别为0.382±0.118、0.433±0.198和0.244±0.220mg·cm^(-2)。平均粒径3μm珍珠粉的透皮吸收效果最好。Scanning electron microscope,X-ray powder diffraction and infrared spectrum were used to study size distribution and mineral composition of pearl powder with average sizes of 0.3μm, 3μm and 10μm;KM rats skin was as experimental barrier, operated by TP-6 Intellectual Transdermal Tester was used to establish and ultraviolet-visible spectrophotometer was utilized to determine Ca^(2+) content to compare Ca^(2+) transdermal rate and 24h cumulative penetration. The results were: pearl powder of 0.3μm agglomerated, pearl powder of 3μm had uniform particle size yet pearl powder of 10μm had particle size of great difference;the main mineral composition of three kinds of pearl powder is aragonite;the transdermal rates were respectively 0.0055, 0.0089 and 0.0010 mg·cm^(-2)·h^(-1) and 24h cumulative penetration were respectively 0.382 ±0.118, 0.433±0.198 and 0.244±0.220mg·cm^(-2). The pearl powder of 3μm showed the best transdermal absorption among the three pearl powders.

关 键 词：珍珠粉 透皮吸收 扫描电镜 X-粉末衍射 红外光谱 

分 类 号：R284.5[医药卫生—中药学] R945[医药卫生—中医学]