美沙拉嗪、肠炎宁胶囊联合双歧三联活菌胶囊治疗溃疡性结肠炎疗效的影响研究  

Study on the Effect of Mesalazine,Changyanning Capsule and Bifidobacterium Triple Viable Capsule on the Treatment of ulcerative Colitis

作　　者：马丽娜[1] MA Lina(Department of Gastroenterology,Zhengzhou Second People's Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市第二人民医院消化内科二病区,河南郑州450000

出　　处：《临床研究》2023年第4期118-121,共4页Clinical Research

摘　　要：目的 探讨美沙拉嗪、肠炎宁胶囊联合双歧三联活菌胶囊治疗溃疡性结肠炎疗效的影响。方法 本研究选取2020年1月至2022年12月郑州市第二人民医院收治的90例溃疡性结肠炎患者按随机数字表法分组,常规组给予美沙拉嗪、肠炎宁胶囊治疗(45例),联合组在常规组用药基础上应用双歧三联活菌胶囊(45例)。比较两组疗效、肠黏膜屏障修复情况、肠道菌群及免疫功能,并观察其用药后不良反应。结果 联合组治疗有效率(95.56%)高于常规组(80.00%),差异有统计学意义(P<0.05)。两组疗程结束时内毒素(ET)、D-乳酸及二胺氧化酶(DAO)水平均低于入院24 h,且联合组低于常规组,差异有统计学意义(P<0.05)。两组疗程结束时乳酸杆菌、双歧杆菌数量显著高于入院24 h,其粪肠球菌及大肠杆菌数量均低于入院24 h,且联合组改善幅度大于常规组,差异有统计学意义(P<0.05)。两组疗程结束时外周静脉血免疫球蛋白G(IgG)水平、CD4^(+)的百分比及CD4^(+)/CD8^(+)细胞比值均高于入院24 h;且联合组高于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率(11.11%VS 13.33%)比较,差异无统计学意义(P>0.05)。结论 美沙拉嗪、肠炎宁胶囊联合双歧三联活菌胶囊应用于临床溃疡性结肠炎治疗中可获得确切疗效,患者肠黏膜屏障、肠道菌群及免疫功能均得到明显改善,且不良反应相对较少、安全性良好。Objective To investigate the effect of mesalazine,Changyanning capsule and Bifidobacterium triple viable capsule on the treatment of ulcerative colitis.Methods In this study,90 patients with ulcerative colitis admitted to the Second People's Hospital of Zhengzhou City from January 2020 to December 2022 were randomly divided into two groups:the conventional group was treated with mesalazine and Changyanning capsule(45 cases),and the combined group was treated with Bifidobacterium triple viable capsule(45 cases)on the basis of the conventional group.The efficacy,intestinal mucosal barrier repair,intestinal flora,and immune function of the two groups were compared,and the adverse reactions after treatment were observed.Results The effective rate of treatment in the combined group(95.56%)was higher than that in the conventional group(80.00%),with a statistically significant difference(P<0.05).The levels of endotoxin(ET),D-lactic acid,and diamine oxidase(DAO)at the end of treatment were lower than those after 24 hours of admission in both groups,the combined group was lower than the conventional group,and the difference was statistically significant(P<0.05).At the end of the treatment period,the number of lactic acid bacteria and bifidobacteria in the two groups was significantly higher than that in the 24 hours after admission,while the number of Enterococcus faecalis and Escherichia coli in the combined group was lower than that in the conventional group,with a statistically significant difference(P<0.05).The levels of immunoglobulin G(IgG),the percentage of CD4^(+),and the ratio of CD4^(+)/CD8^(+) cells in peripheral venous blood at the end of treatment in both groups were higher than those at 24 hours after admission,the combined group was higher than the conventional group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(11.11%VS 13.33%)(P>0.05).Conclusion The application of mesalazine,Changyanning c

关 键 词：美沙拉嗪 肠炎宁胶囊 双歧三联活菌胶囊 溃疡性结肠炎 肠黏膜屏障 免疫功能 

分 类 号：R574.62[医药卫生—消化系统]