增生性玻璃体视网膜病变发生机制主要信号通路研究进展  

Research progress on signaling pathways related to drug research in proliferative vitreoretinopathy

作　　者：韩寒[1] 于金国[1] 颜华[1] Han Han;Yu Jinguo;Yan Hua(Department of Ophthalmology,Tianjin Medical University General Hospital,Tianjin Key Laboratory of Ocular Trauma,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院眼科,天津市眼外伤研究与转化重点实验室,天津300052

出　　处：《中华眼科杂志》2023年第3期225-230,共6页Chinese Journal of Ophthalmology

摘　　要：增生性玻璃体视网膜病变(PVR)是发生在视网膜上的无血管纤维增生性疾病,主要病理改变为视网膜色素上皮细胞(RPE)及胶质细胞在玻璃体和视网膜上增殖和牵拉。基础研究证实PVR的形成和多条信号通路有关,主要包括NF-κB信号通路,MAPK及其下游信号通路,JAK/STAT信号通路,PI3K/Akt信号通路,凝血酶及其受体通路,TGF-β及下游信号通路,North信号通路及Wnt/β-连环蛋白信号通路等。本文总结了PVR形成机制中的主要信号通路的研究进展,为PVR药物治疗研究提供依据和支持。Proliferative vitreoretinopathy(PVR)is an avascular fibroproliferative disease that occurs in the retina.The main pathological changes are the proliferation and traction of retinal pigment epithelial cells(RPE)and glial cells on the vitreous and retina.Basic research has confirmed that the formation of PVR is related to multiple signaling pathways,including NK-κB signaling pathway,MAPK and its downstream signaling pathways,JAK/STAT signaling pathway,PI3K/Akt signaling pathway,thrombin and its receptor pathway,TGF-βand downstream signaling pathway,North signaling pathway and Wnt/β-catenin signaling pathway,etc.This review summarizes the research progress of the main signaling pathways in the formation mechanism of PVR,and provides the basis and support for the research of PVR drug therapy.

关 键 词：玻璃体视网膜病 增生性 视网膜色素上皮 信号传导 

分 类 号：R774.1[医药卫生—眼科]