二氢吲哚-2,3-二酮衍生物抑菌活性研究进展  

Research Progress in Antibacterial Activity of Indoline-2,3-dione Derivatives

作　　者：谭画元 张广龙 吉礼涛 王钦 卢奕朵 欧阳贵平[1] 王贞超[1,2,3] 李洙锐 Tan Huayuan;Zhang Guanglong;Ji Litao;Wang Qin;Lu Yiduo;Ouyang Guiping;Wang Zhenchao;Li Zhurui(School of Pharmaceutical Science;State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering/Key Laboratory of Ministry of Education,Guizhou University;Guizhou Engineering Laboratory for Synthetic Drugs,Guiyang,550025)

机构地区：[1]贵州大学药学院 [2]贵州大学绿色农药与农业生物工程教育部重点实验室 [3]贵州省合成药物工程实验室,贵阳550025

出　　处：《化学通报》2023年第3期300-305,共6页Chemistry

基　　金：国家自然科学基金项目(21867004,22007022);贵州省科技计划平台项目(黔科合平台人才20185781);贵州省科技计划项目(黔科合基础-ZZK[2021]重点034)资助。

摘　　要：二氢吲哚-2,3-二酮是一种结构简单且应用广泛的药物小分子,其衍生物的合成、结构和药理活性等备受关注。已有报道表明二氢吲哚-2,3-二酮具有抗菌、抗衰老、降血脂、抗癫痫、抗病毒等多种生物活性。本文主要围绕抑菌生物活性,对国内外关于二氢吲哚-2,3-二酮类化合物的构效关系进行分析总结,为后期该类新型抗菌化合物的设计合成提供参考。Indoline-2,3-dione is a small drug molecule with simple structure and wide application.The syntheses,structures and pharmacological activities of its derivatives have attracted much attention.It has been reported that indoline-2,3-dione has various biological activities such as antibacterial,antiaging,hypolipidemic,antiepileptic and antiviral activities.This paper mainly focuses on the antibacterial biological activity,and analyzes and summarizes the studies on structure-activity relationship of indoline-2,3-dione compounds at home and abroad,and provides a reference for the design and syntheses of such new antibacterial compounds in futrue.

关 键 词：二氢吲哚-2 3-二酮 抑菌活性 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]