磷脂酸肌醇-3-激酶/蛋白激酶B信号通路在肺部疾病中的作用研究进展  

Research progress on the role of phosphatidylinositol-3-kinase/protein kinase B signalingpathway in lung disease

作　　者：许洋洋(综述) 王文丽(审校)[2] XU Yangyang;WANG Wenli(The First Clinical College,Liaoning University of Traditional Chinese Medicine,Liaoning,Shenyang 110032,China;Department of Paediatrics,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学第一临床学院,辽宁沈阳110032 [2]辽宁中医药大学附属医院儿科,辽宁沈阳110032

出　　处：《现代医药卫生》2023年第6期1002-1005,共4页Journal of Modern Medicine & Health

基　　金：辽宁省教育厅科学技术研究一般项目(L201904)。

摘　　要：磷脂酸肌醇-3-激酶(PI3K)/蛋白激酶B(Akt)信号通路是细胞内与增殖、分化和凋亡相关的信号通路,是机体自我保护的重要通路。PI3K被激活后会使其下游分子Akt磷酸化,进而抑制细胞凋亡、调控细胞生存及增殖。PI3K/Akt信号通路在众多肺系疾病,如急性肺损伤、肺炎、哮喘、肺纤维化、肺癌等的发展进程中起着重要作用。该文对PI3K/Akt信号通路在肺系疾病进展中的作用机制进行了综述。The phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)signaling pathway is an intracellular signal pathway related to proliferation,differentiation and apoptosis,and an important pathway for the body′s self-protection.When PI3K is activated,it will phosphorylate its downstream molecule Akt,and then inhibit cell apoptosis,regulate cell survival and proliferation.PI3K/Akt signaling pathway plays an important role in the development of many lung diseases,such as acute lung injury,pneumonia,asthma,pulmonary fibrosis,lung cancer,etc.The article reviews the mechanism of PI3K/Akt signaling pathway in the progression of pulmonary diseases.

关 键 词：PI3K/AKT通路 肺系疾病 综述 

分 类 号：R-1[医药卫生]