垂体柄阻断综合征发病机制及临床特征研究进展  

Research progress on pathogenesis and clinical characteristics ofpituitary stalk interruption syndrome

作　　者：胡彦利 王文韬(综述) 陈宗兰(审校) HU Yanli;WANG Wentao;CHEN Zonglan(College of Clinical Medicine,Jining Medical University,Jining,Shandong 272067,China;Department of Endocrinology Genetics and Metabolism,Affiliated Hospital of Jining Medical University,Jining,Shandong 272029,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272067 [2]济宁医学院附属医院内分泌遗传代谢科,山东济宁272029

出　　处：《现代医药卫生》2023年第6期1006-1010,共5页Journal of Modern Medicine & Health

基　　金：山东省自然科学基金资助项目(ZR2018PH009);济宁医学院附属医院博士科研启动基金项目(2017-BS-15)。

摘　　要：垂体柄阻断综合征(PSIS)是一种罕见垂体发育异常的疾病,其临床特征因垂体激素缺乏的种类和程度不同而表现各异。目前,PSIS病因尚不明确,其致病机制可能与围生期损伤及相关基因突变有关。PSIS临床表现复杂多样,极易导致漏诊及误诊。该文对PSIS发病机制及诊治进展进行了综述,旨在为该疾病的临床诊疗提供参考。Pituitary stalk interruption syndrome(PSIS)is a rare hypophyseal dysplasia disease.Its clinical characteristics vary with the type and degree of pituitary hormone deficiency.At present,the etiology of PSIS is not clear,and its pathogenic mechanism may be related to perinatal injury and related gene mutations.The clinical manifestations of PSIS are complex and diverse,which can easily lead to missed diagnosis and misdiagnosis.The article reviews the progress in pathogenesis,diagnosis and treatment of PSIS,in order to provide reference for the clinical diagnosis and treatment of this disease.

关 键 词：垂体柄阻断综合征 垂体功能减退 基因突变 综述 

分 类 号：R584.2[医药卫生—内分泌] R584.3[医药卫生—内科学]