基于ReHo探索抑郁症脑功能与外周血炎症因子的相关性  

Correlation between brain function and peripheral inflammatory factors in depression based on ReHo

作　　者：罗屹 何家恺 郭春蕾 孙继飞 马跃 高山山 陈庆燕 张樟进[3] 荣培晶[2] 方继良[1] LUO Yi;HE Jiakai;GUO Chunlei;SUN Jifei;MA Yue;GAO Shanshan;CHENG Qingyan;ZHANG Zhangjin;RONG Peijing;FANG Jiliang(Department of Radiology,Guang’anmen Hospital of Chinese Academy of Traditional Chinese Medicine,Beijing 100053,China.)

机构地区：[1]中国中医科学院广安门医院放射科,北京100053 [2]中国中医科学院针灸研究所,北京100700 [3]香港大学中医药学院,中国香港999077

出　　处：《中国中西医结合影像学杂志》2023年第2期107-111,126,共6页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：科技部国家重点研发计划(2018YFC1705800);国家自然科学基金面上项目(82174282);中国中医科学院广安门医院科研项目结余经费课题项目(2022094)。

摘　　要：目的:通过分析抑郁症患者脑区局部一致性(ReHo)值与外周血炎症因子的相关性,探索抑郁症发生的机制。方法:收集25例抑郁症患者(患者组)及25例健康人(健康组)。2组均行静息态fMRI扫描,血清高敏C反应蛋白(hs-CRP)、白介素-2(IL-2)、肿瘤坏死因子α(TNF-α)检测,以及17项汉密尔顿抑郁量表(HAMD-17)、14项汉密尔顿焦虑量表(HAMA-14)的评定。观察2组的全脑ReHo值与血清炎症因子水平的相关性,以及与炎症因子相关的脑区。进一步分析炎症因子相关脑区的ReHo值与HAMD-17评分、HAMA-14评分的相关性。结果:患者组双侧壳核/苍白球的ReHo值与hs-CRP(左侧:r=0.86,P<0.005;右侧:r=0.77,P<0.005)、IL-2(左侧:r=0.72,P<0.005;右侧:r=0.71,P<0.005)、TNF-α(左侧:r=0.69,P<0.005;右侧:r=0.64,P<0.005)均呈正相关,双侧尾状核的ReHo值与hs-CRP呈负相关(左侧:r=-0.72,P<0.005;右侧:r=-0.74,P<0.005),左侧尾状核的ReHo值与IL-2呈负相关(r=-0.75,P<0.005)。健康组炎症因子与各脑区ReHo值未发现相关性。患者组炎症因子相关脑区与临床量表评分的Pearson相关分析发现,与hs-CRP相关的左侧壳核/苍白球ReHo值与HAMD-17评分(r=-0.457,P=0.022)、HAMA-14评分(r=-0.518,P=0.008)呈负相关,右侧壳核/苍白球ReHo值与HAMA-14评分呈负相关(r=-0.422,P=0.036),右侧尾状核ReHo值与HAMA-14评分呈正相关(r=0.419,P=0.037);与IL-2相关的左侧壳核/苍白球ReHo值与HAMD-17评分(r=-0.406,P=0.044)、HAMA-14评分(r=-0.411,P=0.041)均呈负相关;与TNF-α相关的右侧壳核/苍白球ReHo值与HAMA-14评分呈负相关(r=-0.445,P=0.026)。结论:抑郁症患者纹状体/基底节灰质核团与炎症因子明显相关,为抑郁症的炎症假说提供了新证据;纹状体/基底节灰质脑区可能为研发抑郁症治疗方法提供了潜在的影像标志物。Objective:To explore the mechanisms of depression by analyzing the correlation between the value of regional homogeneity(ReHo)in brain regions and peripheral blood inflammatory factors in depression patients.Methods:Twenty-five depression patients and 25 healthy individuals matched for gender,age,and education were collected.Resting-state fMRI scans,serum high-sensitivity C-reactive protein(hs-CRP),IL-2,TNF-αtests and clinical scores on the 17-item Hamilton Depression Scale(HAMD-17)and 14-item Hamilton Anxiety Scale(HAMA-14)were performed in both groups.The correlation between the whole brain ReHo values and serum inflammatory factor levels was observed in both groups,and the brain area related to inflammatory factors were found.Then,the correlation between ReHo values in inflammatory factor-related brain areas and HAMD-17,HAMA-14 scores was analyzed.Results:In the depreesion group,ReHo values in the bilateral putamen/pallidum were positively correlated with hs-CRP(left,r=0.86,P<0.005;right,r=0.77,P<0.005),IL-2(left,r=0.72,P<0.005;right,r=0.71,P<0.005),and TNF-α(left,r=0.69,P<0.005;right,r=0.64,P<0.005);and ReHo in the bilateral caudate nucleus was negatively correlated with hs-CRP(left,r=-0.72,P<0.005;right,r=-0.74,P<0.005),ReHo in the left caudate nucleus was negatively correlated with IL-2(r=-0.75,P<0.005).However,no correlation was found between inflammatory factors and ReHo values in various brain regions in healthy subjects.Pearson correlation analysis of brain regions associated with inflammatory factors and clinical scale scores in depressed patients revealed that the left putamen/pallidum ReHo values associated with hs-CRP were negatively correlated with HAMD-17 and HAMA-14 scores(r=-0.457,-0.518,both P<0.05),the right putamen/pallidum ReHo value was negatively correlated with HAMA-14 score(r=-0.422,P=0.036)and the right caudate nucleus ReHo value was positively correlated with HAMA-14 score(r=0.419,P=0.037).The ReHo value in the left putamen/pallidum associated with IL-2 was negatively correlated with

关 键 词：抑郁症 功能磁共振成像 炎症因子 纹状体 

分 类 号：R749.4[医药卫生—神经病学与精神病学]